小剂量肝素治疗危重儿伴全身炎症反应综合征的疗效观察  

The Clinical Effect of Low-Dose Heparin Infusion on Critically Ill in the Children with SIRS

作　　者：陈新权[1] 付四毛[1] 梁桂明[1] 

机构地区：[1]中山市博爱医院儿科,广东中山528403

出　　处：《实用临床医学（江西）》2006年第10期140-141,144,共3页Practical Clinical Medicine

摘　　要：目的:观察小剂量肝素持续静脉滴注对伴全身炎症反应综合征(SIRS)的危重儿临床疗效及患儿血小板计数、C反应蛋白(CRP)水平变化。方法:对符合诊断标准的115例SIRS患儿随机分为间断用药组和持续用药组,观察两组临床效果及血小板计数及CRP水平变化。结果:两组治疗前后比较,持续用药组,血小板计数均明显升高,CRP水平均明显下降(均P<0.05),与间断用药组相比,持续用药组多脏器功能不全(MODS)发生率有显著降低(P<0.05),SIRS的持续时间缩短。结论:持续小剂量肝素静脉滴注疗效优于间断用药。Objective： To investigate the clinical effect of low-dose heparin infusion on critically ill of the children with SIRS and the effect on the count of platelet, the level of C-reactive protein （CRP）. Methods： One hundred and fifteen patients with SIRS were included in the prospective randomized control trial. All the patients were divided into continuous infusion group （A） and intermittent infusion group （B）. Clinical effect, count of platelet and level of CRP were observed before and after heparin infusion. Results： After heparin infusion treatment, the level of CRP and morbidity of multiple organ dysfunction syndrome （MODS） in group A were significantly decreased compared to group B, and the count of platelet in group A was significantly higher than that in group B. Conclusion： Continuous heparin infusion is better than intermittent heparin infusion, which could significantly improve the outcome of critically ill children.

关 键 词：肝素 全身炎症反应综合征 血小板 C反应蛋白 

分 类 号：R720.597[医药卫生—急诊医学]