蕲蛇酶对急性脑梗死的疗效及安全性评价  

The Effect and Safety of Acutobin in Acute Cerebral Infarction

作　　者：马建芳[1] 曾爱萍[2] 马烨[1] 陈宏[1] 谢德辉[1] 孔祥峰[1] 

机构地区：[1]中国人民解放军第476医院,福州350002 [2]中国人民解放军454医院肝科,南京210012

出　　处：《海峡药学》2006年第5期118-120,共3页Strait Pharmaceutical Journal

摘　　要：目的评价蕲蛇酶对急性脑梗死的疗效及安全性。方法急性脑梗死90例随机分为两组，两组午龄、性别、病因及基础用药具有可比性。治疗组（47例）和对照组（43例）。治疗组给予蕲蛇酶0．75u，静脉注射，每日1次共7～14d；对照组仅用常规治疗。观察治疗前后的凝血功能、TCD参数、临床神经功能缺损程度评分、Barthel指数、头颅CT变化及用药副作用。结果治疗组血浆Fbg含量明显降低（P〈0，01）；TCD明显改善（P〈0．01）；临床神经功能缺损程度评分下降（P〈0．001）；头颅CT示脑梗死面积缩小，脑水肿减轻（P〈0.01）；无明显出血事件等副作用发生。结论蕲蛇酶是治疗急性脑梗死的安全有效药物之一。OBJECTIVE To evaluate the effect and safety of Acutobin in acute cerebral infarction. METHODS 90 patients with acute cerebral infarction were randomly divided into observed group and control group ;It has significant statistic meaning among age, sex, pathogeny and basic medicine treatment between the two groups. Observed groups （47cases） was given Acutobin 0. 75u qd, iv. 7 - 14 d, control group was given routine treatment. To observe the coagulation system. TCD parameter neurological damage were valued. Barthel index. CT and the medical side effect. RESULTS Observed group Fbg were decreased significantly （P〈0.01） ;TCD index showed obvious improvement （P〈0.01） ; neurological damage were decreased （P〈0.01）;CT showed adecrease in cerebral infarction size and edema zone was smaller than in control group,there has no side effect. CONCLUSION Acutobin is valid and safe in curing acute cerebral infarction.

关 键 词：急性脑梗死 蕲蛇酶 治疗 

分 类 号：R969.4[医药卫生—药理学]