褪黑素对冈田酸致NG108-15和SH-sY5Y细胞活性减弱的影响  

The Effects of Melatonin on Okadaic Acid-induced Viability Decrease in NG 108-15 cell and SH-SY5Y cell

作　　者：吴敏霞[1] 许盈[2] 谢捷明[2] 俞昌喜[2] 

机构地区：[1]福建医科大学电镜室,福州350004 [2]福建医科大学药学院药理系,福州350004

出　　处：《海峡药学》2006年第5期178-180,共3页Strait Pharmaceutical Journal

基　　金：福建省自然科学基金资助(C0010013)

摘　　要：目的观察褪黑素对冈田酸(okadaic acid,OA)致细胞活性减弱的影响。方法以光学显微镜和M TT法观察OA对细胞形态和活性的影响及M LT的拮抗作用。结果OA作用后细胞形态改变明显,突起回缩,细胞活性明显减弱,M LT作用后细胞活性显著提高。结论褪黑素可对抗OA致AD样细胞形态改变和活性减弱。OBJECTIVE To observe the effects of melatonin on okadaic acid-induced cell viabillity in NG-15 and SH-SYSY cell. METHODS Microscope and MTT test were used to observe cell shape and viability. RESULTS OA can reduce cell viability and melatonin can improve cell viabillity. CONCLUSION Melatonin can antagonize OA-induce cell viability decrease.

关 键 词：冈田酸 阿欠茨海默病 褪黑素 

分 类 号：R977.1[医药卫生—药品]