凝血-纤溶动态图在危重症肾功能衰竭患者中的临床应用  

Clinical application of blood coagulation and fibrinolysis dynamic pattern in critical patients with acute renal failure

作　　者：陈抗侵[1] 李波[2] 汪毅[3] 刘作金[2] 叶友坤[2] 龚建平[2] 

机构地区：[1]重庆市涪陵中心医院肾内科,408000 [2]重庆医科大学附属第二医院肝胆外科,400010 [3]重庆市涪陵中心医院急救部,408000

出　　处：《重庆医学》2006年第21期1969-1970,共2页Chongqing medicine

摘　　要：目的探讨危重症患者肾功能与凝血功能变化关系。方法72例危重症患者根据血肌酐值分为正常组(Scr<130μmol/L)和肾衰组(Scr≥130μmol/L),检测两组凝血-纤溶动态图,记录反应时间(CST)、凝固时间(CT)、溶解时间(FT)、平衡时间(BLT)、最大振幅(ME)、平衡指数(BLE)、聚合速度(ACE)和溶解速度(AFE)。结果肾衰组CST、CT和FT延长,BLT缩短,ME增加,ACE、AFE和BLE均降低。结论危重症患者发生ARF时,血液呈高凝和纤溶活性增加状态。Objective To investigate the changes of renal and blood coagulation functions in critical patients. Methods According to the serum ereatinine value（Ser）, the seventy-two critical patients were divided into two groups, the control group （Ser 130μmol/L） and the abnormal group （Scr ≥ 130μmol/L）. Parameters of coagulation and fibrinolysis dynamic pattern were compared between the two groups by t-test, including coagulation start time （CST）, coagulation time （CT）, fibrinolysis time （FT）, balance level time （BLT）, max extent （ME）, balance level exponent （BLE）, accelerating coagulation effect （ACE） and accelerating fibrinolysis effect （AFE）. Results Compared with control group, CST, CT, FT and ME were increased, BLT, ACE, AFE and BLE were decreased in the abnormal group. Conclusion It has a high level of activity of blood coagulation and secondary activity of fibrinolysis in critical patient with acute renal failure.

关 键 词：危重症 急性肾功能衰竭 凝血-纤溶动态图 

分 类 号：R692.5[医药卫生—泌尿科学] R446.61[医药卫生—外科学]