辛伐他汀对急性心肌梗死冠状动脉经皮介入治疗后心肌血流灌注的影响  

Effect of simvastatin on myocardium reperfusion in patients with acute ST segment elevation myocardial infarction after emergency percutaneous coronary intervention

作　　者：薛书峰[1] 娄书花[1] 潘广杰[1] 马惠芳[1] 金军[1] 

机构地区：[1]洛阳市中心医院心内科,河南省洛阳市471000

出　　处：《中国心血管病研究》2006年第11期825-827,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨辛伐他汀对急性心肌梗死患者急诊冠状动脉经皮介入治疗术后心肌血流灌注的影响。方法81例行急诊冠状动脉经皮介入治疗术的急性心肌梗死患者,按之前服用辛伐他汀的情况分为四组:A组15例,服用时间超过6个月;B组19例,服用时间1～6个月;C组17例,服用时间少于1个月;D组30例,未服用。比较各组校正的TIMI帧数计数(CTFC)和1h内ST段回落情况。结果A组和B组CTFC较D组较小(P<0.01),且术后1hST段回落较D组明显(P<0.01)。结论长期服用辛伐他汀,可有效改善急性心肌梗死患者急诊冠状动脉经皮介入治疗术后心肌血流灌注。Objective To explore the effect of simvastatin on myocardium perfusion in patients with acute ST segment elevation myocardial infarction （STEMI） after emergency percutaneous coronary intervention （PCI）. Methods Eight-one patients with STEMI were divided into four groups： group A （n=15,administrated sinmvastatin 20 mg/d for at lest 6 months before PCI ）, group B （n = 19, administrated sinmvastatin 20 mg/d for 1-6 months before PCI ）, group C （n= 17, administrated sinmvastatin 20 mg/d no more than 1 months before PCI）, group D （n=30,none of sinmvastatin was administrated before PCI）. The corrected TIMI frame count （CTFC） and ST segment resolution were measured and compared among four grups. Results The CTFC was less and ST segment resolution was obvious in group A and B compared with groups D （P〈0.01）. Conclusion Adminsistration of sinmvastain may significantly improve myocardium perfusion in patients with STEMI after PCI.

关 键 词：斯伐他汀 心肌梗塞 血管成形术 经腔 经皮冠状动脉 心肌再灌注 

分 类 号：R542.22[医药卫生—心血管疾病]