原发性高血压病患者醛固酮逃逸现象的临床观察  

The aldosterone escape in essential hypertensive patients

作　　者：付红莉[1] 房振英[1] 赵三明[1] 

机构地区：[1]太原市人民医院山西省心血管病医院心内科,山西省太原市030001

出　　处：《中国心血管病研究》2006年第11期840-842,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的观察原发性高血压病患者使用血管紧张素转换酶抑制剂(ACEI)依那普利后并发的醛固酮逃逸现象。方法65例原发性高血压病患者使用依那普利治疗,分别于治疗前及治疗后1、3、6个月采血,检测血管紧张素Ⅱ和醛固酮浓度,根据治疗3个月时的醛固酮浓度,判断有无并发醛固酮逃逸。结果依那普利治疗后1个月,AngⅡ、Ald与治疗前相比均下降,但3个月时,AngⅡ有所升高,Ald明显增高。65例中有28例并发醛固酮逃逸,发生率约43%。结论原发性高血压病患者长期(3个月以上)使用ACEI后,部分患者会出现醛固酮逃逸现象。Objective To investigate aldosterone escape during angiotensin-converting enzyme inhibitor （ACEI） therapy in essential hypertensive（EH） patients. Methods 65 EH patients were treated with ACEI -enalapril. Plasma angiotensin Ⅱ（AngⅡ） and aldosterone（Ald） concentrations were measured by commercial radioimmunoassay after 1,3,6 months treatment respectively. Aldosterone escape was estimated by the plasma Ald levels after 3 months treatment. Results After 1 month enalapril treatment, beth the plasma Ang Ⅱ and Aid concentrations of the patients decreased compared with before treatment. But after 3 months treatment, the plasma Ang Ⅱ levels increased slightly, the plasma Aid levels increased significantly. Aldosterone escape was observed in 28 of 65 patients after 3 months enalapril treatment,the incidence of aldosterone escape was 43%. Conclusion Aldosterone escape may occur during continuous（〉3 months） ACEI therapy in some of EH patients.

关 键 词：高血压 醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病]