石膏炮制前后的生肌药效比较研究  

Comparative study of the effects of Gypsum Fibrosum and Gypsum Fibrosum Preparatum in promoting granulation

作　　者：李祥[1] 刘元芬[1] 项晓人[2] 周一彪[1] 张之磊[1] 

机构地区：[1]南京中医药大学药学院药物化学教研室,江苏南京210029 [2]南京中医药大学江苏省针灸学重点实验室,江苏南京210029

出　　处：《中西医结合学报》2006年第6期624-627,共4页Journal of Chinese Integrative Medicine

基　　金：国家"十五"重大科技专项"创新药物和中药现代化"资助项目(No.2001BA701A55-32)

摘　　要：目的考察生、煅石膏的生肌作用。方法于大鼠背部两侧脱毛区用手术刀切割直径约为1.5cm圆形创口2个,间距约为2cm,深达肌层,肌层伤口厚度约为0.15cm,建立大鼠肌层创口模型。将40只形成创口的SD大鼠随机分为4组模型组、贝复济治疗组、生石膏治疗组、煅石膏治疗组。然后于创口处分别撒敷生、煅石膏细粉,喷洒药物贝复济,分别于第8和第14天观察创口肉芽组织的修复状态。结果煅石膏治疗组与模型组和生石膏治疗组比较,大鼠创口成纤维细胞数、肉芽组织中毛细血管数和肉芽组织中毛细血管面积均明显增加,差异有统计学意义(P<0.01);与贝复济治疗组比较,两者差异无统计学意义(P>0.05)。生石膏治疗组与模型组比较,差异无统计学意义(P>0.05)。结论煅石膏能促进大鼠伤口成纤维细胞和毛细血管的形成,加快肉芽组织增生,从而促进皮肤创口的愈合。石膏煅制后药效发生改变,具有生肌作用。Objective： To investigate the effects of Gypsum Fibrosum and Gypsum Fibrosum Preparatum in promoting granulation. Methods： The wounds of muscle layer were produced in rats by using surgical operation. Two round wounds, with diameter about 1.5 cm, were cut at the depilatory area of two sides of the back of each rat, with an interval of 2 cm, deep to muscle layer, and the thickness of the knife wound of muscle layer was about 0. 15 cm. Forty SD rats with the wounds were randomly divided into 4 groups-untreated group, beifuji-treated group, Gypsum Fibrosum-treated group and Gypsum Fibrosum Preparatum-treated group, with 10 rats in each group. Then the wounds were sprinkled with powders of Gypsum Fibrosum and Gypsum Fibrosum Preparatum, or sprayed with beifuji solution, respectively. The healing state of granulation tissues of the wounds was observed at the eighth and fourteenth day respectively. Results. The number of fibroblasts, the number of capillary tubes and the area of capillary tubes in granulation tissue of wounds in the Gypsum Fibrosum Preparatum-treated group were significantly higher than those in the untreated group and Gypsum Fibrosum-treated group （ P 〈 0. 01 ）. There were no statistical differences between the Gypsum Fibrosum Preparatum-treated group and the beifuji-treated group. However, Gypsum Fibrosum-treated group showed no obvious differences compared to the untreated group （P〉0. 05）. Conclusions： Gypsum Fibrosum Preparatum can accelerate the formation of collagenoblast and micrangium in wounds, and the proliferation of granulation tissues, thus promoting the skin wounds to healing. The effect of Gypsum Fibrosum is changed after being calcined, and Gypsum Fibrosum Preparatum has obvious effect in promoting granulation.

关 键 词：石膏 煅石膏 创口 肉芽组织 生肌 

分 类 号：R285.5[医药卫生—中药学]