双氯芬酸二乙胺盐凝胶皮肤毒性实验  

Experimental Study of Dermal Toxicity from Diclofenac Diethylamine Salt Gel

作　　者：李继洪[1] 张彤[1] 代冬梅[1] 

机构地区：[1]湖北省医药工业研究院,武汉430061

出　　处：《医药导报》2006年第11期1116-1118,共3页Herald of Medicine

摘　　要：目的观察双氯芬酸二乙胺盐凝胶经皮用药的安全性。方法对家兔进行皮肤急性毒性实验、皮肤刺激性实验;对豚鼠进行皮肤变态反应实验。结果双氯芬酸二乙胺盐凝胶均未引起家兔毒性反应;对家兔完整皮肤无刺激作用,但对破损皮肤有轻度刺激作用;对豚鼠皮肤无致变态反应作用。结论双氯芬酸二乙胺盐凝胶经皮给药安全。Objective To observe the safety of dielofenac diethylamine salt gel after external use. Methods Acute dermal toxicity test and dermal irritation test were conducted in rabbits, and dermal sensitivity test was performed in guinea pigs. Results Diclofenac diethylamine salt gel had no acute toxicity to the skin of rabbits with no stimulating action to the intact skin, but with a mild stimulation to the broken skin. Skin allergic reactions didn ＂t appear in guinea pigs. Conclusion Diclofenac diethylamine salt gel is safe for transdermal administration.

关 键 词：双氯芬酸二乙胺盐 急性毒性 刺激性 变态反应性 

分 类 号：R971.1[医药卫生—药品] R967[医药卫生—药学]