恶性肿瘤患者深部感染白色念珠菌的基因分型  

Genotyping of Candida albicans from Maligant Tumor Patients with Deep Candida albicans Infection

作　　者：谭肖鹂[1] 汪华侨[2] 何丽容[1] 潘武宾[3] 张革[3] 

机构地区：[1]中山大学肿瘤防治中心检验科 [2]中山大学基础医学院人体解剖教研室,广州510080 [3]中山大学药学院微生物制药实验室,广州510080

出　　处：《热带医学杂志》2006年第11期1157-1159,共3页Journal of Tropical Medicine

基　　金：中山大学百人计划科研启动基金(No.36000-3253285)

摘　　要：目的对引起恶性肿瘤患者深部真菌感染的白色念珠菌进行基因分型。方法研究对象90例,CHROMagarCandida鉴定培养基分离鉴定白色念珠菌,PCR方法鉴定并进行ABC基因分型。结果引起恶性肿瘤患者深部真菌感染的白色念珠菌基因型分别为A型(36/90,40%)、B型(32/90,35.6%)、C型(22/90,24.4%),取自同一病人身体不同部位和相同部位的标本均分离出不同基因型白色念珠菌。结论恶性肿瘤患者深部白色念珠菌感染由不同基因型的白色念珠菌株引起。Objective To investigate the genotypes of Candida albicans from cancer patients with deep fungal infection. Methods Ninety C. a/b/cans isolates were obtained from CHROMagar Candida medium. The ABC genotypic subgroups were determined by PCR method. Results Among these isolates, 36/90 （40%） belonged to A subgroup, 32/90 （35.6%） belong to B subgroup,and 22/90 （24.4%） belonged to C subgroup. Candida of different genotypes were found from the same site of the same patient. Conclusion Cancer patients with deep fungal infection may have infection of C. albicans of different genotypes.

关 键 词：白色念珠菌 基因型 恶性肿瘤 

分 类 号：R379.4[医药卫生—病原生物学]