心安颗粒对病毒性心肌炎小鼠的防治作用  

The Protective Effect of Xinan Granule on Viral Myocarditis in Mice

作　　者：陈美娟[1] 杨思进[1] 肖顺汉[1] 李亮[1] 李华[1] 

机构地区：[1]泸州医学院药理教研室,四川泸州646000

出　　处：《中国中医药信息杂志》2006年第11期37-38,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：四川省教育厅重点项目[川教科(1998)143号];四川省中医药管理局基金项目(2000-18)

摘　　要：目的探讨心安颗粒对病毒性心肌炎小鼠的心肌保护作用。方法采用BALB/C小鼠腹腔注射柯萨奇病毒B3(CVB3),建立小鼠病毒性心肌炎模型。小鼠随机分为空白对照组,模型组,心安颗粒10、20、40g原药材/(kg·d)组和病毒唑[0.1g/(kg·d)]组。一批小鼠先注射CVB32h后给药,连续用药7d,第8天处死小鼠,取血测定血清乳酸脱氢酶(LDH),取心脏称重并作心肌病理学检查;另一批小鼠先用药2d,注射CVB3后用药7d,观察20d,记录小鼠存活时间。结果心安颗粒治疗组与模型组相比,心脏指数降低,心表面出血点检出率明显减少,心肌组织病理损伤减轻,血清LDH含量明显降低,小鼠存活时间明显延长。结论心安颗粒对病毒性心肌炎小鼠具有防治作用。Objective To investigate the protective effect of Xinan granule on viral myocarditis in mice. Methods Viral myocarditis model was made by intraperitoneal inoculation with Coxaackie virus B3 in BALB/C mice. Mice were randomly devided into six groups： the normal control group, the model control group, the Xinan granulel0, 20, 40 g/（kg · d） groups and the Binduzuo 0.1 g/（kg · d） group. After CVB3 infection 2 h, one set of mice were given drugs for 7 d. Blood and heart samples were obtained on the 8th day after CVB3 infection. The myocardial histopathologic changes were observed. The serum cardiac enzyme （LDH） were measured. The others were given drugs for 2 d before CVB3 infection, and for 7ds after CVB3 infection. The survival time were recorded for 20 ds. Results The myocardial histopathologic damage, LDH, cardiac index, punctate hemorrhage on heart surface in Xinan group reduced more significantly than that of the model control group. The survival time in Xinan group were longer than that of the model control group. Conclusion Xinan granule may have the preventional and therapeutic effect on viral myocarditis in mice.

关 键 词：心安颗粒 病毒性心肌炎 乳酸脱氢酶 病理学 BALB/C小鼠 

分 类 号：R285.5[医药卫生—中药学]