Synthesis and Antifungal Activity of Novel Chiral α-Aminophosphonates Containing Fluorine Moiety  

作　　者：杨松 高兴文 刁春玲 宋宝安 金林红 徐广芳 张国平 王伟 胡德禹 薛伟 周霞 卢平 

机构地区：[1]Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, Guizhou 550025, China

出　　处：《Chinese Journal of Chemistry》2006年第11期1581-1588,共8页中国化学（英文版）

基　　金：Project supported by the National Key Program for Basic Research （Nos. 2003CB114404, 2005CCA01500）, the National Natural Science Foundation of China （No. 20362004） and the Doctoral Program Foundation of the Ministry of Education, China （No. 20040657003）.

摘　　要：Chiral α-aminophosphonates were synthesized using （R） or （S）-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by ^1H NMR, ^19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.Chiral α-aminophosphonates were synthesized using （R） or （S）-1-phenylethylamine in the presence of BF3·Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by ^1H NMR, ^19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.

关 键 词：chiral aminophosphonate fluorine moiety antifungal activity microwave irradiation SYNTHESIS 

分 类 号：O623.736[理学—有机化学] R914.4[理学—化学]