在微流控芯片上合成对甲氧基苯甲醛肟  

Synthesis of 4-Methoxybenzaldehyde Oxime in a Microfluidic Chip

作　　者：穆金霞[1] 殷学锋[1] 王彦广[1] 

机构地区：[1]浙江大学化学系,杭州310027

出　　处：《高等学校化学学报》2006年第11期2114-2116,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20475049)资助

摘　　要：In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip.The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate.The effect of reaction time on the yield was determined and compared with the standard batch system.The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate,less consumption of reactants and labor contaminant,which proved microfluidic chip to be a powerful tool for synthetic applications.In this paper the design and development of a novel experiment system and method for organic synthesis in a microfluidic were described chip. The phase-transfer reaction for the synthesis of 4-methoxy-benzaldehyde oxime from 4-methoxybenzaldehyde and hydroxylammonium chloride was carried out in glass microfluidic chips by using a negative pressure system to control the transformation reactants through the microchannels at a constant flow rate. The effect of reaction time on the yield was determined and compared with the standard batch system. The demonstrated advantages of organic synthesis in microfluidic chip included faster reaction rate, less consumption of reactants and labor contaminant, which proved microfluidic chip to be a powerful tool for synthetic applications.

关 键 词：微流控芯片 相转移反应 对甲氧基苯甲醛肟 

分 类 号：O621[理学—有机化学]