Vascular endothelial growth factor expressing mesen-chymal stem cells improves cardiac function in chronic myocardial infarction in pigs  

作　　者：YI Fu GUO Wen-yi Lue An-lin WANG Hai-chang LI Hu LI Wei-jie LIU Bing ZHANG Dian-xin LUAN Rong-hua CHENG He-xiang LI Fei QIN Tao ZHAO Zhi-jing GAO Feng JIA Guo-liang 

机构地区：[1]Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi＇an 710032, China [2]Department of Physiology, Fourth Military Medical University, Xi＇ an 710032, China

出　　处：《Chinese Medical Journal》2006年第19期1664-1668,共5页中华医学杂志（英文版）

基　　金：This work was supported in part by grants from the National Nature Science Foundation of China (No. 30471923 and No. 30570667) and Shaanxi Provincial Science Grant (No. 2004C2-03).

摘　　要：Transplantation of mesenchymal stem cells （MSCs） for myocardial reconstruction has shown promise in both animal models and human phase 1 clinical studies. Vascular endothelial growth factor （VEGF） is a strong therapeutic agent for treating ischaemia by inducing angiogenesis. The feasibility of ex vivo MSCs mediated gene transfer is documented. Matsumoto and colleagues have recently reported genetically engineered MSCs carrying VEGF165 delivery for revascularization in a model of acute myocardial infarction （MI）. The promising data from our laboratory in both angiogenesis and MSCs transplantation in cunicular heart model of acute MI have prompted us to attempt the combined and simultaneous application of the two strategies.Transplantation of mesenchymal stem cells （MSCs） for myocardial reconstruction has shown promise in both animal models and human phase 1 clinical studies. Vascular endothelial growth factor （VEGF） is a strong therapeutic agent for treating ischaemia by inducing angiogenesis. The feasibility of ex vivo MSCs mediated gene transfer is documented. Matsumoto and colleagues have recently reported genetically engineered MSCs carrying VEGF165 delivery for revascularization in a model of acute myocardial infarction （MI）. The promising data from our laboratory in both angiogenesis and MSCs transplantation in cunicular heart model of acute MI have prompted us to attempt the combined and simultaneous application of the two strategies.

关 键 词：myocardial infarction mesenchymal stem cell transplantation vascular endothelial growth factor ventricular function 

分 类 号：R542.22[医药卫生—心血管疾病]