Effects of Bushen Zhuanggu Formul on interleukin-6 production and bone metabolism of the ovariectomized rats  

作　　者：Lulu Chen Huiqing Li Tianshu Zeng Wenfang Xia Juan Zheng Min Zhou 

机构地区：[1]Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022,China

出　　处：《Journal of Nanjing Medical University》2006年第4期193-196,共4页南京医科大学学报（英文版）

基　　金：National Natural Science Foundation of China(39770930)

摘　　要：Objective： To observe the effects of Bushen Zhuanggu Formul on intedeukin 6 （IL-6） level and bone metabolism of the ovariectomized rats, and to explore the possible mechanism of preventing and treating postmenopausal osteo porosis by traditional Chinese Formul. Methods： SD rats were randomly divided into 4 groups： normal control group （N）, ovariectomized control group （OVX）, estrogen-treated group （OVX＋E） traditional and Chinese medicine-treated group （OVX＋ CM）. After treaanent, IL-6 levels in rat bone tissue media and serum were examined by ELISA. The proximal tibias（PTM） of rats were undecalcified for quantitative bone histomorphometry. Results： Compared with OVX group, both Bushen Zhuanggu medicine and estrogen decreased IL-6 level in rat bone tissue media. However, the effects of Bushen Zhuanggu Formul were weaker than those of estrogen. Furthermore, Bushen Zhuanggu Formul and estrogen produced a reduction in bone turnover by inhibiting bone formation and bone resorption at the same time. Conclusion： Bushen Zhuanggu Formul prevents ovariectomic bone loss by inhibiting IL-6 production in rat bone tissues.Objective： To observe the effects of Bushen Zhuanggu Formul on intedeukin 6 （IL-6） level and bone metabolism of the ovariectomized rats, and to explore the possible mechanism of preventing and treating postmenopausal osteo porosis by traditional Chinese Formul. Methods： SD rats were randomly divided into 4 groups： normal control group （N）, ovariectomized control group （OVX）, estrogen-treated group （OVX＋E） traditional and Chinese medicine-treated group （OVX＋ CM）. After treaanent, IL-6 levels in rat bone tissue media and serum were examined by ELISA. The proximal tibias（PTM） of rats were undecalcified for quantitative bone histomorphometry. Results： Compared with OVX group, both Bushen Zhuanggu medicine and estrogen decreased IL-6 level in rat bone tissue media. However, the effects of Bushen Zhuanggu Formul were weaker than those of estrogen. Furthermore, Bushen Zhuanggu Formul and estrogen produced a reduction in bone turnover by inhibiting bone formation and bone resorption at the same time. Conclusion： Bushen Zhuanggu Formul prevents ovariectomic bone loss by inhibiting IL-6 production in rat bone tissues.

关 键 词：Bushen Zhuanggu Formul bone tissue INTERLEUKIN-6 bone histomorphometry 

分 类 号：R711.5[医药卫生—妇产科学]