新型中药栓塞剂介入治疗甲状腺机能亢进症的动物实验研究  

An Animal Experhnentai Study on embolization agent of Traditional Chinese Medicine in lnterventional Treatment of Hyperthyroidism

作　　者：周仁[1] 王守春[1] 李昌祁[1] 时利平[1] 冯佳庆[1] 曹伟军[1] 温斌[1] 李志春[1] 倪世宇[1] 杜月娟[1] 邢春艳[1] 赵玉国[1] 张海梅[1] 宋长春[1] 

机构地区：[1]黑龙江大庆龙南医院,大庆163453

出　　处：《现代生物医学进展》2006年第10期68-69,75,共3页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金项目(D0356)

摘　　要：目的：观察并评价新型中药栓塞剂介入治疗甲状腺机能亢进症的动物实验研究情况。方法：检测并分析新型中药栓塞剂介入治疗甲状腺机能亢进症的动物实验研究资料。结果：1．无菌检查：根据中国药典2005版的灭菌检查方法,对经灭菌的样品进行厌氧菌、需氧菌检查,无上述菌落。2．热源检查：依据中国药典2005版规定的热源检查方法,进行栓塞剂热源检查,结果表明无热源反应发生。3．溶血实验：溶血实验表明,栓塞剂在37℃保温24h后无溶血现象(红细胞全部下沉,上层液元色澄明)。4．栓塞剂使用后,动物无剧烈不良反应,无发音困难。术后5-7d开始脱毛、少叫、懒动、表情淡漠、反应迟钝、进食减少、体重减轻,呈甲状腺功能减低表现。5．血清T_3、T_4、TSH及血钙水平均与实验前有显著盖异(P＜0．05)。结论：我们研究的新型复方中药栓塞剂不但具有良好的栓塞效果同时具有抗炎、止血、痛等治疗作用,总之,复方中药栓塞剂有望成为介入治疗甲亢并能被普遍接受的新型田态栓塞剂,具有广阔应用前景。Objective： To observe and evaluate the animal experimental study on a new type of embolization agent of Traditional Chinese Medicine in interventional treatment of hyperthyroidism. Methods： Firstly, Baiji gum was extracted from Balj i. Secondly, embolization agent（EA） of traditional Chinese medicine（TCM） were prepared. After that, 5 dogs were selected, among which, 3 were, treated with the novel EA of TCM, 2, PVA. T3, T4, TSH and blood calcium levels of all dogs before embohzatlon and 7 days, 14 days, 211 days, 28 years after embolization. Results： Asepsis examination, pyrogen test and hemolysis test were all up to the standards. Thyroid arteries of the two groups of animals were all embohzed. The animals had no severe adverse reactions, difficult pronunciation, and showed symptoms of hypothyroidism. Compared with before embohzation,there were significant differences in serum T3, T4, TSH and blood calcium levels （P〈 0.05）. Conclusion： The new type of embolization agent studied in this experiment has not only good embohtic effects but anti - inflammatory, hemostatic and analgesic effects as well. In a word, the compoud embohzation agent of traditional Chinese medicien may have a huge potential as a new solid embohzation agent for interventional treatment of hyperthyroidism and could be widely accepted.

关 键 词：中药栓塞剂 介入治疗 动物实验 

分 类 号：P944[天文地球—自然地理学] R582.1[医药卫生—内分泌]