黄芩甙治疗细菌性脑膜炎的临床研究  

Clinical observation of baicalin used in treatment of bacterial meningitis

作　　者：麦水强[1] 闫玉欣[1] 丁刚[1] 廖长征 李有国[1] 黄梅英[1] 

机构地区：[1]深圳市龙岗区人民医院儿科,518172 [2]深圳市龙岗区中心医院

出　　处：《中国妇幼保健》2006年第21期2948-2950,共3页Maternal and Child Health Care of China

基　　金：深圳市科技立项课题(200405254)

摘　　要：目的:探索黄芩甙对细菌性脑膜炎的治疗作用。方法:63例细菌性脑膜炎病儿随机分为2组,疾病对照组31例单用抗生素治疗,治疗组32例采用抗生素+黄芩甙治疗。采用E lisa法、G riess法检测两组病儿治疗前后的血浆及脑脊液中肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、一氧化氮(NO)的水平,比较两组病儿的临床疗效、死亡率及后遗症发生率。结果:①治疗后治疗组病儿血浆及脑脊液TNF-α、IL-1及NO水平均低于疾病对照组,差异显著(P<0.05)。②治疗组的临床疗效优于疾病对照组,差异显著(P<0.05)。③治疗组的死亡率及后遗症发生率低于疾病对照组,差异显著(P<0.05)。结论:黄芩甙对细菌性脑膜炎具有一定的治疗作用,其机理可能与抑制体内TNF-α、IL-1、NO等炎症因子的过度释放有关。Objective： To study the effect of baicalin used in treatment of bacterial meningitis. Methods： 63 cases of bacterial meningitis were divided into two groups, 32 cases of treatment group were treated with baicalin and antibiotic, 31 cases of control group were treated with antibiotic. The levels of TNF - α, IL - 1, NO of plasma and cerebrospinal fluid （CSF） were determined in two groups by ELISA method and Griess method to compare the curative effect, mortality and sequelae rate between two groups. Results： ①The levels of TNF - α, IL - 1, NO of plasma and CSF of treatment group were significantly lower than those of control group （ P 〈 0. 05 ） ;②The curative effect of treatment group was significantly better than that of control group （ P 〈 0. 05 ） ; ③The mortality and sequelae rate of treatment group was significantly lower than those of control group （ P 〈 0. 05 ） . Conclusion： Baicalin has some effect on treatment of bacterial meningitis, the treatment mechanism is inferred to restrain the excessive release of TNF - α, IL - 1, NO in the body.

关 键 词：黄芩甙 细菌性脑膜炎 治疗 临床研究 

分 类 号：R725.1[医药卫生—儿科]