茄病镰刀菌致小腿慢性溃疡1例报告及病原真菌超微结构的研究  

Chronic leg ulcer caused by Fusarium sonali:A case report and super-microstructure investigation

作　　者：冉玉平[1] 王晓霞[1] 代亚玲[1] 彭雪梅[2] 张杰[3] 周光平[1] 

机构地区：[1]四川大学华西医院皮肤性病科,成都610041 [2]四川大学华西医院基础与法医学院电镜室 [3]四川大学华西医院病理科电镜室

出　　处：《中国真菌学杂志》2006年第4期197-199,210,共4页Chinese Journal of Mycology

摘　　要：报道1例55岁男性农民,因右小腿溃疡4个月余就诊。取其溃疡组织作真菌培养和病理检查,真菌培养在含氯霉素、放线菌酮和不含氯霉素、放线菌酮的沙堡弱培养基中27℃都长出白色棉絮状菌落,而在不含氯霉素、放线菌酮条件下生长更好;在马玲薯培养基中长出镰刀状大分生孢子,菌种鉴定为茄病镰刀菌。8d后从溃疡处再取标本培养仍为茄病镰刀菌生长。病理切片经银染色后发现念珠状分隔菌丝,用透射电镜对病变组织内的菌体形态进行了超微结构研究。予伊曲康唑口服治疗,但患者未复诊而失访。We report a 55-year-old male farmer, suffered from ulcer on his right leg for more than four months. The patient was taken a biopsy to do fungal culture and pathological examination. White and cottony mould colony grew out on the Sabouraud dextrose agar （SDA） with or without chloramphenicol and cycloheximide at the second day under 27℃, and growth better on the late medium. On the potato dextrose agar （PDA） , the fungus developed sickle-like macroconidia. It was identified as Fusarium sonali. Repeat isolation from the ulcerated tissue was taken at 8th day after the first cultivation and Fusarium sonali still grew. Prayer beadslike septal hyphae were found in the biopsy tissue by silver staining pathologically. The super-microstructure of the pathogen in vivo was investigated under the transmission electron microscopy. Itraconazole was taken orally but the patient lost follow-up.

关 键 词：茄病镰刀菌 溃疡 超微结构 

分 类 号：R379.9[医药卫生—病原生物学]