赤芍甘草冲剂对D-半乳糖诱导肝损伤的保护作用  

Protective effects of Chishaogancaochongji on chemical liver injury induced by D-galactosamine in mice

作　　者：王迪生[1] 高继君[1] 张承光[1] 项雷[1] 杨青杨[1] 邢亚群[1] 岑德意[2] 董六一[2] 陈志武[2] 

机构地区：[1]蚌埠医学院第二附属医院药剂科 [2]安徽医科大学药理教研室

出　　处：《中国临床药理学与治疗学》2006年第9期1026-1029,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:探讨赤芍甘草冲剂对D-半乳糖胺(D-GalN)致小鼠急性化学性肝损伤的保护作用及可能机制。方法:建立D-GalN诱导小鼠化学性肝损伤模型,分光光度法检测血清中丙氨酸氨基转移酶(ALT)、天冬门氨酸氨基转移酶(AST)水平和肝匀浆丙二醛(MDA)、一氧化氮(NO)含量。结果:赤芍甘草冲剂(200、400、800 mg.kg-1)灌胃给药均能降低血清中升高的转氨酶水平,使升高的肝脾指数降低;同时发现赤芍甘草冲剂可降低肝匀浆中升高的MDA和NO水平。结论:赤芍甘草冲剂对D-GalN致小鼠急性化学性肝损伤具有保护作用,其机制与其抗氧化活性等有关。AIM： To investigate the effects of Ch- ishaogaochongji D-galactosamine-induced liver injury in mice. METHODS： The chemical-associated liver injury in mouse was induced made by administration of D-GaiN. The serum alanine aminotransferase （ALT） and aspartate aminotransferase （AST） level, and malondiadehyde （MDA） and nitric oxide （NO） level in liver homogenate were assayed by chemochromometry. RESULTS： Chishaogancaochongji （200,400, 800 mg· kg^-1） was able to decrease levels of serum transaminases （ALT, AST）, liver index and thymus index significantly. Furthermore, Chishaogancaochongji also decreased MDA content and NO level in liver homogenate. CONCLUSION： Chishaogancaochongji has protective effect on chemical-associated liver injury in mice.

关 键 词：小鼠 赤芍甘草冲剂 D-半乳糖胺 分光光 度法 化学性肝损伤模型 

分 类 号：R965.2[医药卫生—药理学]