羟丙基-β-环糊精对葛根素溶解性与角膜渗透性的影响  

Effect of Hydroxypropyl Beta Cyclodextrin on Aqueous Solubility and Corneal Permeation of Puerarin

作　　者：吴纯洁[1] 齐红艺 黄春燕[2] 苏诚[2] 侯世祥[1] 

机构地区：[1]四川大学华西药学院,成都610041 [2]成都中医药大学,成都610072

出　　处：《中国药学杂志》2006年第20期1565-1568,共4页Chinese Pharmaceutical Journal

基　　金：四川省教育厅基金项目(2004C005)

摘　　要：目的研究羟丙基-β-环糊精(HPCD)对葛根素溶解性与角膜透过性的影响。方法采用了相溶解度法和离体角膜扩散实验。结果在不同浓度HPCD下,葛根素的相溶解曲线呈AL型;随着HPCD浓度的增大,葛根素的表观渗透系数减小。50 g.L-1HPCD增溶的表观渗透系数分别是以150 g.L-1HPCD和40 g.L-1PVP增溶的3.12和2.86倍,但150 g.L-1HPCD与40 g.L-1PVP增溶的表观渗透系数相比没有显著性差异(P>0.05)。结论HPCD能增加葛根素的溶解度与提高其角膜透过性。OBJECTIVE To investigate the effect of hydroxypmpyl beta cyclodextrin（HPCD）on aqueous solubility and corneal permeation of puerarin. METHODS The solubility of puerarin with HPCD was investigated by phase-solubility method. The permeability of puerarin across isolated rabbits cornea was measured in vitro. RESULTS An AL-type phase solubility curve was obtained. The apparent permeation coefficient of puemrin decreased as the concentration of HPCD increased. The apparent permeation coefficient at 50 g·L^-1 HPCD level was increased by 3.12 times as that at 150 g·L^-1 HPCD level, and 2.86 times as that at 40 g·L^-1 PVP level. There was no significant difference（ P 〉 0. 05 ） between the apparent permeation coefficient at 150 g·L^-1 HPCD level and 40 g·L^-1 PVP level. CONCLUSION The solubilizing effect of HPCD on puerarin in aqueous solution is good. HPCD enhances the permeability of puerarin across isolated rabbits cornea.

关 键 词：葛根素 羟丙基-Β-环糊精 相溶解度 角膜透过性 

分 类 号：R965[医药卫生—药理学]