子痫前期胎盘低氧诱导因子1α的表达及其与血清胎盘生长因子的相关性  

Relationship of hypoxia-inducible factor-1α expression in placenta and serum placenta growth factor in preeclampsia.

作　　者：周丽[1] 宋荣 乔福元[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院妇产科,430030 [2]广州空军医院,510602

出　　处：《中国优生与遗传杂志》2006年第11期18-19,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的检测正常晚期妊娠和子痫前期患者胎盘低氧诱导因子1α(H IF-1α)和血清胎盘生长因子(P lGF)的水平,探讨它们的相关性及与子痫前期发病的关系。方法免疫组织化学SP法检测40例子痫前期患者及20例正常晚期妊娠胎盘H IF-1α表达,酶联免疫吸附试验(ELISA)检测血清P lGF的水平。结果轻度子痫前期组与重度子痫前期组胎盘H IF-1α表达高于正常晚期妊娠组,两组血清P lGF低于正常晚期妊娠组,差异均有显著性意义(P<0.05)。胎盘H IF-1α的表达与血清P lGF水平呈负相关关系。结论子痫前期患者血清P lGF水平依赖于胎盘H IF-1α表达,两者可能与子痫前期的发病有一定关系。Objective： To detect the expression of hypoxia - inducible factor -1α （ HIF - 1α） in placenta and the expression of placenta growth factor （P1GF） in materunal serum from normal pregnancy and preeclampsia, To investigate their correlation and the relationship with pathogenesis of preeclampsia, Methods： The expression of HIF - 1α in placenta collected from 40 preeclampsia patients and 20 normotensive controls was determined by immunohistochemistry. P1GF level in the maternal venous serum was measured by enzyme linked immunoassay （ELISA）, Results： The expression of HIF- 1α of placental tissues was significantly higher in mild and severe preeclampsia groups than in normal pregnancy group, P1GF level in the maternal serum from mild preeclampsia group and severe preeclampsia group was significantly lower than those from normal pregnancies, Conclusions： P1GF expression in maternal serum was depended on the expression of HIF -1α in placenta. Increased expression of HIF -1α in placental tissues and the decline of P1GF in serum might play important roles in pathogenesis of preeclampsia.

关 键 词：子痫前期 低氧诱导因子1Α 胎盘生长因子 

分 类 号：R714.2[医药卫生—妇产科学]