芍芪多苷对小鼠急性化学性肝损伤的保护作用  

Effects and mechanisms of Shaoqiduogan on mice with chemical liver injury

作　　者：吴丽[1] 魏伟[1] 桂双英[1] 孙妩弋[1] 

机构地区：[1]安徽医科大学临床药理研究所

出　　处：《中国中药杂志》2006年第21期1807-1810,共4页China Journal of Chinese Materia Medica

基　　金：国家"863"资助项目(2002AA2Z3235)

摘　　要：目的:探讨芍芪多苷(SQDG)对CC l4致小鼠急性化学性肝损伤模型的保护作用及可能机制,并对SQDG与白芍总苷、黄芪总皂苷单独用药的特点进行比较。方法:建立CC l4致化学性小鼠急性肝损伤模型,分光光度法检测血清中丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)和肝匀浆中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)含量,HE染色法对肝脏作病理检查。结果:SQDG能显著降低小鼠血清ALT,AST,MDA水平,升高SOD和GSH-Px酶活性,减轻肝细胞损伤。SQDG中剂量与白芍总苷、黄芪总皂苷单独用药比较,具有较好的肝脏保护作用和抗氧化作用。结论:SQDG对CC l4致小鼠急性化学性肝损伤模型具有保护作用。Objective： To study the therapeutic effects and mechanisms of SQDG on carbon tetraehloride-indueed chemical liver injury in mice as well as its possible mechanisms . At the same time the pharmacodynamics of SQDG was compared with TGP or ASTs of effective dose. Method： The model of carbon tetrachloride-induced chemical liver injury in mice was prepared. The levels of ALT, AST, MDA content, SOD and GSH-Px activities in liver homogenate were assayed by spectrophotometry; Meanwhile, hepatic pathological examination was observed. Result： Protective effect of SQDG on carbon tetrachloride-induced chemical liver injury：SQDG was able to significantly decrease serum transaminase levels of chemical liver injury＇s mice induced by carbon tetrachloride, decreased MDA content and improved the reduced SOD and GSH-px levels in liver homogenate. Furthermore, SQDG also attenuate the area and extent of necrosis and reduce the infiltration of inflammatory cell. Compared with TGP or ASTs of effective dose, SQDG has a better effect on carbon tetrachloride-induced chemical liver injury in mice. Conclusion： SQDG can protect mice injured by carbon tetrachloride-induced chemical.

关 键 词：芍芪多苷 白芍总苷 黄芪总皂苷 化学性肝损伤 

分 类 号：R285.5[医药卫生—中药学]