冠心苏合丸系列组方对犬心肌梗死影响的比较药理学研究  

Study on therapeutic effects of series of Muskone on myocardial infarction canines

作　　者：张金艳[1] 马堃[1] 李贻奎[1] 张永涛[1] 吴理茂[2] 李向日[3] 潘理[4] 李连达[1] 

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]浙江大学药学院,浙江杭州310031 [3]北京同仁堂股份有限公司科学研究所,北京100011 [4]沈阳中药制药有限公司,辽宁沈阳110044

出　　处：《中国中药杂志》2006年第20期1702-1705,共4页China Journal of Chinese Materia Medica

基　　金：国家"十五"科技攻关重点项目(2004BA721A10)

摘　　要：目的:观察冠心苏合丸系列组方对实验性犬急性心肌缺血、心肌梗死的影响,阐明其治疗缺血性心脏病的药理作用及特点。方法:采用心外膜电图标测心肌缺血范围及程度,定量组织学(N-BT染色法)测定心肌梗死范围,同时测定血浆内皮素(ET),血栓素B2(TXB2),6-酮-前列腺素F1α(6-Keto-PGFlα)活性的变化,及对相关指标的影响。结果:冠心苏合丸系列组方具有明显改善犬急性心肌缺血和心肌梗死的作用,明显减轻由心外膜电图标测的心肌缺血程度(∑-ST)及范围(N-ST);减小经N-BT染色所显示的梗死区;对心肌缺血及心肌梗死引起ET的活性有明显抑制作用,同时升高血浆6-Keto-PGF1α和6-Keto-PGF1α/TXB2的比值。结论:冠心苏合丸系列组方对心肌梗死有治疗作用。Objective： To observe the effects of the series of Muskone （the Muskone includes Slender Dutchmanspipe Root, Tumuxiang, and not Slender Dutchmanspipe Root） on myocardial ischemia, myocardial infarction and hematological index in experimental canines, and to explain the pharmacological action and characteristic of its therapeutic effect on ischemic heart disease. Method ： The range and degree of myocardial ischemia was evaluated by epicardial electrogram mapping, and the range extent of myocardial infarction was determined by quantitate histology （N-BT staining method）. Meanwhile, the changes of ET,TXB2 ,6-Keto-PGF1a, were determined to study the effects of the series of Muskone on myocardial ischemia, myocardial infarction and hematological index in experimental canines. Result： The series of Muskone can improve myocardial ischemia and infarction in experimental canines, and relieve significantly the degree of myocardial ischemia （∑-ST） determined by epicardial electrogram mapping,decrease the range of myocardial ischemia （N-ST） determined by epicardial electrogram mapping and decrease infarction zone determined by N-BT staining method. And it has a significant inhibition on activity of ET induced by myocardial ischemia and infarction, and increases 6-Keto- PGF1aand 6-Keto-PGF1a/TXB2induced by myocardial isehemia. Conclusion： The series of Muskone has significant therapeutic effect on myocardial infarction.

关 键 词：冠心苏合丸系列方 比较药理学 马兜铃酸 青木香 土木香 

分 类 号：R285.5[医药卫生—中药学]