生半夏中草酸钙针晶的刺激性作用研究  

Study on irritation of calcium oxalate crystal in raw Pinellia ternata

作　　者：钟凌云[1] 吴皓[1] 张科卫[1] 王倩如[1] 

机构地区：[1]南京中医药大学中医药研究院,江苏南京210029

出　　处：《中国中药杂志》2006年第20期1706-1710,共5页China Journal of Chinese Materia Medica

基　　金：江苏省科技厅自然科学基金项目(BK2004153)

摘　　要：目的:验证生半夏中草酸钙针晶的刺激性作用。方法:采用家兔眼刺激实验方法,比较半夏提取草酸钙针晶前后、提取出来的纯草酸钙针晶及半夏水和各种有机溶剂提取液的刺激性作用,并对半夏草酸钙针晶刺激性作用进行量效关系试验。同时对半夏和茜草中所含草酸钙针晶的形状进行显微镜检,并在相同浓度下进行刺激性作用比较。结果:生半夏中的草酸钙针晶具有强烈刺激性,与半夏生品混悬液在针晶含量相同的条件下,对家兔的眼刺激作用基本相同,针晶浓度与家兔眼刺激程度呈现确切的量效关系。结论:生半夏中的草酸钙针晶为半夏的刺激性成分。Objective： Confirm the irritation of needle-like calcium oxalate crystals in raw Pinellia ternata. Method： Comparing the irritations of raw P. ternate containing calcium oxalate crystals, the raw P. ternate no containing calcium oxalate crystals, the pure needle-like calcium oxalate crystals isolated from raw P. ternata, the extracts of water and various solvents from raw P. ternate. by using the model of rabbits＇ eyes. Studying the quantity effect relationship of different concentration suspensions of needle-like calcium oxalate crystal isolated from raw P. ternate on rabbits＇ eyes. 0bserveing the shape and appearance of calcium oxalate crystals in raw P. ternate and raw India Madder Root by the electro microscope and comparing their irritation degrees with the same contents of calcium oxalate crystals. Result： Calcium oxalate crystals in raw P. ternata showed very strong irritation property. Under the same content of calcium oxalate crystals, the irritation of raw P. ternata and pure needle-like calcium oxalate crystals isolated from raw P, ternate had no significant difference. The concentrations of needle-like calcium oxalate crystals were do relative to the degree of irritation on rabbits＇ eyes and they showed undoubted quantity-effect relationship. Conclusion： Calcium oxalate crystal is the irritation component in raw P. ternata.

关 键 词：生半夏 草酸钙针晶 刺激性作用 

分 类 号：R285.5[医药卫生—中药学]