阿托伐他汀对血脂正常的短暂性脑缺血发作患者颈动脉内膜-中层厚度的影响  

Effect of atorvastatin on intima media thickness of the carotid artery in transient ischemic attack patients with normal cholesterol

作　　者：徐国焱[1] 陈玲[1] 吴可贵[1] 陈翠林[1] 王中心[1] 曾向军[1] 

机构地区：[1]福建医科大学附属第一医院干部病房,福州350005

出　　处：《中国医师进修杂志（内科版）》2006年第11期21-23,共3页Chinese Journal of Postgraduates of Medicine

基　　金：中央保健专项资金资助项目(闽C004)

摘　　要：目的观察阿托伐他汀对血脂正常的短暂性脑缺血发作(TIA)患者颈动脉内膜-中层厚度(CA-IMT)的影响。方法双盲、安慰剂对照选择42例TIA患者,随机分为阿托伐他汀组与安慰剂组,应用彩色多普勒超声测定CA-IMT,平均随访18个月,观察CA-IMT及血脂的变化。结果阿托伐他汀组的CA-IMT在0、6个月时与安慰剂组比较差异无统计学意义(P>0.05),18个月后CA-IMT较安慰剂组明显减小(P<0.05);阿托伐他汀组与安慰剂组在0、6、18个月不同时段之间的CA-IMT差异无统计学意义(P>0.05)。阿托伐他汀组6、18个月后总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、甘油三酯(TG)较安慰剂组明显下降(P<0.05或<0.01),高密度脂蛋白-胆固醇(HDL-C)差异无统计学意义(P>0.05)。结论阿托伐他汀可延缓或逆转血脂相对较低的TIA患者CA-IMT的进展,18个月后明显。Objective To investigate if atorvastatin is effective in reducing carotid intima media thickness （CA -IMT） in normocholesterolaemic patients with transient ischemic attack （TIA）. Methods Forty -two patients with TIA were recruited. Patients were randomised to receive atorvastatin（ 5 - 10 mg/d） or placebo daily. Serum concentration of cholesterol and CA - IMT were measured before randomisation and at 6 - and 18 - month intervals. Results CA - IMT was significantly lower in atorvastatin group than that in placebo group at 18 -month （P 〈0.05） ; There was no difference in CA -IMT between the two groups at 6 -month. A significant reduction in total cholesterol （TC）, low density lipoprotein cholesterol （ LDL - C） and triglycerides （TG） was observed at 6 - and 18 - month in patients randomised to the atorvastatin group （ P 〈 0.05 or 〈 0.01 ）. Conclusions The results demonstrate that atorvastatin reduces intima media thickness of the carotid artery in normocholesterolaemic patients with transient ischemic attack at 18 -month.

关 键 词：短暂性脑缺血发作 颈动脉 内膜-中层厚度 阿托伐他刀 

分 类 号：R541.4[医药卫生—心血管疾病]