子宫平滑肌和胎膜内皮素受体-1表达与分娩发动的关系  

Correlation between endothelin-1 receptor expression in myometrium and fetal menbrane and labor onset

作　　者：张燕[1] 王豫黔[2] 

机构地区：[1]蚌埠医学院附属医院妇产科,安徽蚌埠233004 [2]遵义医学院附属医院妇产科,贵州遵义563003

出　　处：《蚌埠医学院学报》2006年第6期612-613,F0003,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨子宫平滑肌和胎膜内皮素受体-1(ETa-R)表达水平与分娩发动的关系。方法:分别于术中取正常晚孕临产组和未临产组(各30例)孕妇子宫平滑肌及胎膜,采用免疫组化SABC法测定子宫平滑肌和胎膜ETa-R的表达,并通过计算机图像分析系统进行定量分析。结果:正常妊娠临产前后子宫平滑肌细胞胞膜、胞质均有ETa-R表达,且临产后其表达范围及强度均较临产前增强,差异均有统计学意义(P<0.01);胎膜组织中ETa-R主要定位于合体滋养细胞和中间滋养细胞,ETa-R表达强度在临产前后没有明显变化(P>0.05),但临产后其阳性细胞率较临产前增强(P<0.01)。结论:分娩发动前、后子宫平滑肌及胎膜组织中ETa-R表达水平升高,并与分娩发动有密切关系,是诱发子宫收缩的重要因素。Objective：To investigate the changes of endothelin-I receptor（ETa-R） expression in human myometrium as well as fetal membranes during the course of labor and its relationship to the labor onset. Methods：Immunohistochemcal SABC method and computer quantitative image analysis were employed to determine the levels of ETa-R in human myometrium and fetal membrane before and during the labor. Results：Mthough the ETa-R was expressed in human myometrium either before or during the parturition,the positive rate and level of ETa-R were significantly higher after the onset of labor （P 〈 0.01 ）. In fetal membranes, the ETa-R was mainly distributed in syncytial trophoblasts and intermediate trophoblasts. The positive rate of ETa-R was increased significantly after the onset of labor（ P 〈 0.01 ） ,whereas there was no significant difference in the level of ETa-R（ P 〉 0.05 ）. Conclusions： The Up-regulation of ETa-R expression in myometrium and fetal membrane during the course of labor suggests that ET-1 may be important in the initiation of human parturition.

关 键 词：分娩发动 受体 内皮素 子宫平滑肌 胎膜内皮素受体-1 

分 类 号：R714.3[医药卫生—妇产科学]