云芝糖肽对丘脑束旁核神经无痛诱发放电的影响  

Effects of Polysaccharide Peptide of Coriolus Versicolor on the Nociceptive Response of Neurons in the Thalamic Parafascicular Nucleus in Rats

作　　者：张惠琴[1] 邵立荣[1] 俞光第[1] 印其章[1] 顾振纶[2] 钱曾年[2] 

机构地区：[1]苏州医学院神经生物学研究室,215007 [2]苏州中药研究所

出　　处：《江苏医药》1996年第11期742-744,共3页Jiangsu Medical Journal

基　　金：香港百草堂有限公司资助

摘　　要：以刺激大鼠坐骨神经作为伤害性刺激，记录丘脑束旁核（Pf）神经元的伤害性放电为指标，观察云芝糖肽（PSP）对这种伤害性反应的影响，并进行药理学分析。结果如下：1．PSP能明显抑制Pf神经元的伤害性放电（P＜0．05）。2．纳洛酮（1mg／kg）能翻转PSP对Pf神经元的伤害性放电的抑制。3．注射5-羟色胺（5－HT）合成抑制剂对氯苯丙氨酸（PCPA）后，PSP的抑制作用消失。以上结果说明了PSP的镇痛作用可能是通过阿片能神经元系统和5－HT能神经元系统的调制而起作用的。The effects of polysaccharide peptide of coriolus versicolor (PSP) on nociceptive response of neurons in the thalamic parafascicular nucleus (Pf), evoked by sciatic nerve stimulations were investigated and analyzed pharmacologically in rats. The main results were as follows: 1. The nociceptive response of Pf neurons in rats was significantly inhibited by PSP(P<0.05) ; 2. The inhibitory effect of PSP was reversed by naloxone (1mg/kg, i. m.); 3. The effect of PSP was no longer exhibited in rats treated with 5-hydroxytryptandne synthesis in hibitor parachlorophenylalanine (PCPA). Experimental results suggest that PSP could bring inhibitory effect on the nociceptive response of Pf neurons, which might be mediated by opioidergic and serotonergic neuronal systems in brain.

关 键 词：云芝糖肽 束旁核 痛诱发放电 中药 神经元 

分 类 号：R285.5[医药卫生—中药学]