阿霉素肾病鼠肾组织SOD、MDA变化的研究  

The Study on SOD and MDA in Renal Tissue in Adriamycininduced Nephrotic Syndrome in Rats

作　　者：何劲松 童云 韩德萱 

机构地区：[1]南京市鼓楼医院肾脏科,210008

出　　处：《江苏医药》1996年第10期674-676,共3页Jiangsu Medical Journal

摘　　要：采用一次性尾静脉注射阿霉素7mg／kg制备大白鼠肾病模型。分为注射后一周、二周、四周三组，同时设立正常对照组，分别测定各组肾皮髓质、血清超氧化物歧化酶（SOD）活性和丙二醛（MDA）水平。结果肾病组肾组织、血清SOD活性和MDA水平明显高于对照组血清SOD／MDA比值明显低于对照组，四周组也明显低于一周和二周组。24小时尿蛋白排泄、血肌酐与肾组织MDA、血清MDA水平呈正相关，与血清SOD／MDA呈负相关，说明脂质过氧化反应参与阿霉素肾病的发病。The possible role of reactive oxygen species in rats model of nephrotic syndrome induced by adriamycin(ADR) was studied,ADR rats were divided to 3 groups, Group Ⅰ 7 days after ADR injection；Group Ⅱ 14days after ADR injection； Group Ⅲ 28 days after ADR injection. Superoxide dismutase(SOD) activites and malondialdehyde (MDA) levels in renal cortico-medullary tissue and serum were measured in ADR groups and normalcontrols. Results showed that SOD activities and MDA levels in renal tissue were significantly increased in ADRgroups,and SOD activities and MDA levels in serum were markedly high in ADR groups,SOD/MDA ratio in serumwas lower in ADR groups Ⅲ than that in normal controls and ADR groups Ⅰ, Ⅱ. We also found that 24-hour urinary protein excretion and serum creatinine showed positive correlation with MDA levels in renal tissue and serum,and negative correlation with SOD/MDA ratio in serum in ADR groups. It is concluded that oxygen products maybe the important mediators in producing glomerular injury and proteinuria in ADR nephrosis.

关 键 词：超氧化物歧化酶 丙二醛 阿霉素 肾病 

分 类 号：R692.02[医药卫生—泌尿科学] R979.14[医药卫生—外科学]