安痛藤对大鼠佐剂性关节炎的实验研究  

The Effects of Cissus assamica on Adjuvant Arthritis in Rats

作　　者：黄丽萍[1] 谢一辉[1] 肖百全[1] 张叶青[1] 

机构地区：[1]江西中医学院,江西南昌330006

出　　处：《时珍国医国药》2006年第11期2139-2140,共2页Lishizhen Medicine and Materia Medica Research

基　　金：江西省教育厅资助课题;赣教技字[2006]226号

摘　　要：目的研究安痛藤对类风湿性关节炎大鼠的影响,观察其镇痛作用。方法建立福氏佐剂诱导大鼠类风湿性关节炎模型;口服安痛藤水煎液,观察药物对实验性大鼠足肿胀的抑制作用;采用化学刺激致小鼠扭体观察安痛藤的镇痛作用。结果与模型组比较,安痛藤水煎液(2.4 g生药/kg,4.8 g生药/kg)其有明显的镇痛作用,能明显地改善AA大鼠原发性炎症和继发性炎症,能明显在减轻AA大鼠的关节肿胀,降低多发性关节炎指数(P<0.01)。结论安痛藤有抗大鼠佐剂性关节炎的作用。Objective To study the effect of Cissus assamica on adjuvant arthritis in rats , as well as its effect on relieving pain. Methods The model of adjavant arthritio in rat was induced by intradermal injection of CFA, The parameter of ankle joint was measured at different time points. The inhibitory effects on paw edema of Cissus assamica were observed, and the effects of relieving pain were measured with writhing experiment on mice. Results Compared with models, Cissus assamica relieved pain on mice and inhibited paw edema on rats significantly. Primarily and succeeding inflammation were ameliorated. Polyarticular arthritis index decreased. Conclusion Cissus assamica has curative effect on AA rats.

关 键 词：安痛藤 类风湿性关节炎 镇痛 

分 类 号：R255.6[医药卫生—中医内科学]