回输的血小板在体内清除机制研究进展  

Advances in the Studies of the Clearance Mechanism of Transfused Platelet Concentrates——Review

作　　者：郭永 韩颖 

机构地区：[1]北京输血医学研究所,北京100850

出　　处：《中国实验血液学杂志》2006年第5期1049-1052,共4页Journal of Experimental Hematology

摘　　要：生理学,病理学方面的研究发现血小板在体内清除主要发生在肝脏和脾脏,但衰老和损伤的血小板被体内清除系统识别和清除的机制还并不清楚。这一机制研究的深入将有助于解决血小板低温保存后体内存活期短,不能较长期发挥作用的难题,为血小板保存提出新的策略。本文就血小板回输体内后的清除机制,包括P-选择蛋白,GPⅠbα及其受体Mac-1和内源性金属蛋白酶在血小板清除进程中的作用等的研究进展作一综述。Platelet clearance has already been studied in physiological and pathological conditions and shown its occurrence mainly in the liver and the spleen. It is still not clear what mechanisms are responsible for recognition and removal of either aged or damaged platelets by the scavenging system. So study of the clearance mechanism will be useful to prolong the survival time of plateletes in vivo. And it may be related to a new strategy to store platelets. This article focuses on the advances in studies of the clearance mechanism of transfused platelet concentrates, including roles of P-selectin, GPIbα and its rectptor Mac-1 in platelet clearance, and effect of endogenous metalloproteinase in platelet clearance .

关 键 词：血小板 血小板保存 清除机制 P-选择蛋白 GPIbα 内源性金属蛋白酶 

分 类 号：R331.143[医药卫生—人体生理学]