珍香胶囊对大鼠子宫内膜异位症模型病灶的影响  

Effects of Zhenxiang capsule on transplanted endometrial tissue of endometriosis in rats

作　　者：曾如辉[1] 罗丽莉[1] 许铭炎[2] 隋旭霞[2] 傅玉才[2] 

机构地区：[1]汕头大学医学院第一附属医院妇科,广东汕头515041 [2]汕头大学医学院细胞衰老实验室,广东汕头515041

出　　处：《中国现代医学杂志》2006年第21期3211-3214,3217,共5页China Journal of Modern Medicine

基　　金：广东省自然科学基金资助项目(5008360);广东省科技计划项目(2003C34413);广东省中医药局科研资助项目(1050135)

摘　　要：目的研究中药珍香胶囊对大鼠子宫内膜异位症(内异症,endometriosis,EMs)模型内异症病灶的影响。方法自身移植法建立SD大鼠内异症模型,随机分成空白对照组、珍香胶囊低剂量治疗组(0.324g/kg)、珍香胶囊中剂量治疗组(0.648g/kg)、珍香胶囊高剂量治疗组(1.296g/kg)和内美通治疗组(0.25mg/kg)。观察用药后各组模型病灶的大小以及组织学观察子宫内膜的生长形态。结果用药4周后,各组间病灶体积没有明显差异。组织病理学显示用药组的异位内膜生长明显受抑制或变性坏死,病灶组织血供不足。量化分析各用药组内膜平均得分明显低于对照组,但各用药组之间的平均分没有明显差异。结论珍香胶囊能够抑制、破坏异位内膜的增长,其作用与内美通相似。在本次实验的剂量范围内其药物作用没有明显的剂量依赖性。[Objective] To investigate the effects of the traditional Chinese medicine Zhenxiang capsule in endometriosis model rats, [Method] 95 sexual mature female SD rats were used in this study, The rat endometriosis model was produced by autotransplantation with uterine tissues, 4 weeks after the autotransplantation, rats were divided randomly into five groups and treated with different dosages of Zhenxiang capsule （0,324 g/kg, 0.678 g/kg, and 1,296 g/kg） through intragastric administration every day for the four consecutive weeks. Nemestran and saline solution were taken as positive and negative controls, respectively. [Result] After 4 weeks treatment, the size of the autotransplants of treated groups was not significantly reduced compared with the control group. However, histopathological examination showed that the growth and cell proliferation of endometrium were marked repressed, or degeneration and necrosis occurred in most of the cases treated with Zhenxiang capsule as well as with Nemestran. Moreover, most of the transplanted tissues of treated groups were short of blood supply. Semiqantitative analysis of endometrium showed statistically significantly lower scores in rats treated with Zhenxiang capsule and Nemestran compared with controls. There was not significant differences among groups with different dosages of Zhenxiang capsule and Nemestran. [Conclusion] Zhenxiang capsule causes repression of ectopic endometrial growth and cell proliferation, and degeneration and necrosis of transplanted endometrial tissues. Zhenxiang capsule is as effective as Nemes- tran to endometriosis in model rats.

关 键 词：子宫内膜异住症 大鼠 珍香胶囊 内美通 

分 类 号：R71[医药卫生—妇产科学]