不同年龄阶段小儿外周血B淋巴细胞CD_(21)表达的差异  

Different Expression of CD_(21) on Peripheral Blood B Lymphocytes in Children in Different Age Periods

作　　者：王琼瑾[1] 张融[1] 

机构地区：[1]东南大学医学院附属扬州医院儿科,江苏扬州225000

出　　处：《实用儿科临床杂志》2006年第21期1494-1495,共2页Journal of Applied Clinical Pediatrics

基　　金：扬州市卫生局科技招标立项课题[2003(19)]

摘　　要：目的测定不同年龄阶段小儿外周血B淋巴细胞CD21表达水平,以探讨其临床意义。方法将住院非感染患儿分成新生儿组、婴幼儿组和儿童组,收集外周血1.8 mL,进行流式细胞仪检测,测定不同年龄组CD21的B淋巴细胞和CD21表达位点数目。结果1.新生儿外周血表达CD21的B淋巴细胞数目明显低于婴幼儿组和儿童组,且随年龄增长,其数值亦呈渐升高趋势。2.B淋巴细胞表达CD21平均荧光强度有渐增强特点。结论随小儿年龄增长,B淋巴细胞CD21表达渐上调,符合不同年龄段小儿免疫系统发育特点,也反映特定年龄段由于B淋巴细胞CD21高表达,而造成对EB病毒的易感性。Objective To investigate the clinical significance of the expression of CD21 on peripheral blood B lymphocytes in different age periods. Methods All the cases was divided into newborn group, infant group and children group. The expression of CD21 on B lymphocytes were analyzed by the flow cytometry. Results 1. The number of CD21 on B lymphocytes of newborn group were obviously lower than those in other two groups; and with growth of a child, the numer tended to grow up. 2. Mean fluorescence intension（MFI）, the expression of CD21 on B lymphocyte, also had the characteristic of increase with the age. Conclusions With the growing up of a child, the expression of CD21 on B lymphocyte has the tendency of up - regulation; which conforms to the feature of immune system development in childhood. Because of the higher expression of CD21 on B lymphocyte in certain age, it has the sensitivity to Epstein - Barr virus infection for children.

关 键 词：B淋巴细胞 CD21 年龄分析 

分 类 号：R725.5[医药卫生—儿科]