降钙素对骨质疏松症治疗的临床观察  

Clinical observiation on calcitonin in management of osteoporosis

作　　者：林伯庚[1] 陈治卿[1] 陈鹭玲[1] 

机构地区：[1]厦门大学附属中山医院老年科,福建厦门361004

出　　处：《中国骨质疏松杂志》2006年第5期490-491,481,共3页Chinese Journal of Osteoporosis

摘　　要：目的研究降钙素在骨质疏松症(OP)治疗中对骨密度(BMD)的作用。方法198例根据自愿选择分为钙剂组92例,降钙素+钙剂组102例,其中各组按疗程分为3个月和6个月两个亚组;钙剂组:每日口服元素钙600mg,维生素D125U。降钙素+钙剂组:每日口服元素钙600mg,维生素D125U;鲑降钙素50IU(商品名密钙息,北京诺华制药有限公司),肌肉注射,每d1次,连续14d,接着隔日1次,连续14次,以后为每周2次直至完成疗程。治疗前及疗程结束后,采用双能X线骨密度仪测定前后位L2-4腰椎及非优势侧(左)股骨颈骨密度。结果降钙素+钙剂组缓解疼痛快而有效。降钙素+钙剂组腰椎和股骨颈骨密度在3个月和6个月治疗后均有显著提高,6个月组骨密度提高大3个月组(P<0·01),腰椎疗效优于股骨颈。结论降钙素治疗骨质疏松症有明显疗效,选择适当的长疗程患者受益更大。Objective To study the influence of calcitonin on bone mineral density （BMD） in osteoporotic patients. Methods Totally, 198 osteoporotic patients were divided into two groups. Patients in Group Ⅰ （ n = 92） were given oral calcium （600mg ＋Vit D3 125U,QD） and those in Group Ⅱ （ n = 102） were given oral calcium and calcitonin （Salcatonin 50 IU, IM, QD × 14 d, then QOD × 28 d, finally twice a week to the end of the course with the same dose of oral cacium and Vit D3 ） . Subgroups were divided according the courses of treatment, ie. 3 months and 6 months. The BMD of lumbar vertebra 2-4 and neck of left femur were measured by duel-energy X-ray absorptiometry before and after the treatment. Results Patients in Group Ⅱ had quicker and more effective pain relief than those in Group i and the BMD was much more increased at both 3 and 6 months after the treatment than that of Group Ⅰ .The BMD at the 6 months was higher than that at the 3 months （ P 〈 0.01）. The effect of the treatment on the lumbar vertebra was better than that of the femur neck. Conclusions Calcitonin is effective in management of osteoporosis and patients would obtain more benefit with relatively longer COUrses.

关 键 词：降钙素 骨质疏松症 骨密度 

分 类 号：R681[医药卫生—骨科学]