光疗前后新生儿的DNA指纹分析  

DNA FINGERPRINTS ANALYSIS OF NEWBORNS TRkATED BY PHOTOTHERAPY

作　　者：王黛[1] 王家锦[1] 辛德丽[1] 张小为 史秀芬 穆莹[1] 

机构地区：[1]北京医科大学人民医院医学遗传科,北京市友谊医院儿科,北京市刑事科学技术研究所

出　　处：《北京医科大学学报》1996年第4期290-291,共2页Journal of Peking University(Health Sciences)

摘　　要：目的：了解光疗对新生儿的ＤＮＡ是否有损伤。方法：采用ＬＥ１１．８小卫星探针，经Ｓｏｕｔｈｅｒｎ印迹法检测接受光疗前后新生儿外周血的ＤＮＡ指纹谱带。结果：２２例接受光疗前后的新生儿ＤＮＡ指纹相比，均未见到任何谱带的改变。结论：光疗未引起新生儿的ＤＮＡ损伤，应用国产蓝光治疗器对高胆红素血症新生儿在４８ｈ内治疗是安全的。Objective:To investigate whether there is DNA damage of infants treated by phototherapy.Methods:Detection of DNA Fingerprints of the infants by Southern blot hybridization using LE 11.8 probe,Results:No bands change of DNA Fingerprints of 22 infants treated before and during pho-totherapy.Conclusion:No DNA damage was seen in the infants treated by phototherapy. It is safe for infants to be treated by phototherapy within 48 hours.

关 键 词：光疗法 DNA指纹图谱 DNA损伤 新生儿 

分 类 号：R722.105[医药卫生—儿科]