野罂粟总生物碱镇痛作用  

Study on analgesic characteristics of total alkaloids of paparer mudicaul

作　　者：杨宇杰[1] 王春民 党晓伟 梅爱敏[1] 

机构地区：[1]承德医学院,河北承德067000 [2]承德颈复康药业集团有限公司,河北承德067000

出　　处：《中国医院药学杂志》2006年第11期1338-1340,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的：研究野罂粟总生物碱（total alkaloids of Papaver nudicaul，TAPN）的镇痛作用特点。方法：采用小鼠热板法和大鼠电刺激甩尾法两种致痛模型研究TAPN镇痛作用特点。结果：小鼠热板法和大鼠电刺激甩尾法致病实验结果表明：ipTAPN具有明显的镇痛作用，其作用强度约为吗啡的1／5～1/4。单次给药的镇痛作用达峰时间与吗啡相似，均在20min以内，但镇痛作用持续时间明显长于吗啡，可达4h以上。与吗啡明显不同的是．TAPN的镇痛作用无耐受性。结论：TAPN具有明显的镇痛作用，作用强度弱于吗啡．约为吗啡的1／5-1/4，但镇痛作用维持时间明显长于吗啡，可持续4h以上．且其镇痛作用无耐受性。OBJECYTIVE The aim is to study the analgesic characteristics of total alkaloids of Papaver mudicaul （TAPN）. METHODS The analgesic characteristics of TAPN were studied by hot-plate and electric-evoked methods of mice and rats. RESULTS In the experimental algesimetry models of hot-plate and electric-evoked methods,TAPN exerted a remarkable analgesic action. Its potency was 1/5-1/4 times weaker than that of morphine. The peak time of the action of TAPN was similar to that of morphine and within 20 minutes, but the analgesic duration of TAPN was longer than that of morphine and lasted more than 4 hours. The analgesic action of TAPN was free from tolerance. CONCLUSION TAPN has significant analgesic actions, its potency is weaker than that of morphine. The analgesic duration of TAPN is longer than that of morphine and lasts more than 4 hours. The analgesic action of TAPN is free from tolerance.

关 键 词：野罂粟总生物碱 镇痛作用 

分 类 号：R961.1[医药卫生—药理学]