黄连解毒汤对大鼠结肠炎组织损伤的影响  

The influence of HuangLianJieDu Decoction on tissue injuries of experimental colitis in rat

作　　者：廖泽云[1] 姜锦林[2] 

机构地区：[1]湖北民族学院医学院,湖北恩师445000 [2]湖北民族学院附属医院,湖北恩师445000

出　　处：《实用医药杂志》2006年第11期1349-1351,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的研究黄连解毒汤对实验大鼠结肠炎组织损伤的保护作用及其机制。方法用Wirst大鼠建立结肠炎动物模型,灌服用药2周后,取结肠组织评价大鼠结肠黏膜损伤指数(CMDI),检测结肠髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH—PX)活性及丙二醛(MDA)的含量。结果不同剂量黄连解毒汤(10、30、50ml／kg体重)灌胃用药后均能不同程度降低模型大鼠结肠黏膜损伤指数(CMDI)和MPO活性、减少MDA含量,提高SOD、GSH—PX活性,且与用药剂量呈一定量效关系。结论黄连解毒汤通过抗脂质过氧化,对大鼠结肠炎结肠损伤进行修复,减轻结肠损伤,抑制结肠炎大鼠炎症反应。Objective To study the protection effect of HuangLianJieDu Decoction on injured tissue of colitis rats. Methods Rat colitis model was established,and subjected to HuangLianJieDu Decoction by clyster once a day; after two weeks, the eolonmueosa damage index（CMDl） was evaluated. The activity of MPO, GSH-PX, SOD and the levels of MDA in the colon were measured. Results HuangLianJieDu Decoction （10,30,50ml/kg·bw） can decrease the activity of CMDI,MPO and the levels of MDA, increase the activity of SOD,CSH-PX in model rats. Conclusion Treatment with HuangLianJieDu Decoction can alleviate the colon injury in colitis rats, and eliminate oxygen free radical and repair wound.

关 键 词：黄连解毒汤 结肠炎 抗氧化作用 

分 类 号：R285.5[医药卫生—中药学]