^(99m)Tc-LDL显像检测实验性动脉粥样硬化斑块  

Experimental atheromatous plaque imaging with ^(99m)Tc labelled low density lipoproteins in rabbit

作　　者：王全师[1] 陈宇[2] 吴春山[2] 张益金 刘德宣[3] 

机构地区：[1]白求恩医科大学一院干部病房ECT室,长春130021 [2]白求恩医科大学一院干部病房ECT室内科,长春130021 [3]卫生部长春生物制品研究所

出　　处：《中华核医学杂志》1996年第4期247-249,共3页Chinese Journal of Nuclear Medicine

摘　　要：为探讨^(99m)Tc-低密度脂蛋白(LDL)动脉粥样硬化显像的临床应用前景,对9只动脉粥样硬化模型兔和4只对照兔进行^(99m)Tc-LDL 显像,并与放射自显影及组织病理学结果进行了对比分析。结果:高胆固醇高脂肪膳食建立兔动脉粥样硬化模型其成功率为100%;静脉注射^(99m)Tc-LDL24小时,动脉粥样硬化斑块显示良好,9只动脉粥样硬化兔中有8只显示出与动脉粥样硬化斑块分布相一致的放射性聚集影,并与放射自显影显示的黑度有很好的一致性;4只对照兔动脉内未出现放射性聚集影。表明^(99m)Tc-LDL 显像对动脉粥样硬化的诊断具有良好的前景。PURPOSE Atheromatous plaque imaging with ^(99m)Tc labeled low density lipoproteins(^(99m)Tc-LDL) were evaluated in rabbits for its clinical prospect.METHODS The ^(99m)Tc-LDL atheromatous plaque imagings were performed in 9 rabbit models of atherosclerosis and 4 controls.The imagings were compared with autoradiograpbic and pathological results.RESULTS The rabbit models of atherosclerosis by high cholesterol and high fat diet were successful in 100%.The atheromatous plaques well visualized in 8 of 9 rabbit models 24 hours after injection.The site and density of radioactive accumulation was closely correlated in autora- diograpby also.There was no radioactive spot in 4 controls.CONCLUSIONS ^(99m)Tc-LDL imaging may have a significant value for the diagnosis of atherosclerosis.

关 键 词：动脉粥样硬化 放射性核素显像 脂蛋白 锝^99M 

分 类 号：R543.5[医药卫生—心血管疾病]