甲状腺疾病的甲状腺球蛋白基因活性研究  

Study of thyroglobulin gene activity in thyroid disease

作　　者：任邦明[1] 李建国[1] 陈显煜[1] 李小放[1] 敬兴果[1] 吴国桢[1] 倪济苍 彭惠民[2] 唐吟宇[2] 郭玉萍[2] 张静[2] 

机构地区：[1]重庆医科大学第一医院核医学科,630042 [2]重庆医科大学基础医学部生物学教研室

出　　处：《中华核医学杂志》1996年第4期250-252,共3页Chinese Journal of Nuclear Medicine

摘　　要：为探讨甲状腺球蛋白(Tg)基因活性的改变对甲状腺疾病临床诊断的价值,对330例甲状腺病变者的 Tg 含量及其基因位点变异进行了研究。包括甲状腺癌30例(^(131)I 治疗21例,手术治疗9例),桥本甲状腺炎89例(甲状腺功能正常59例,甲状腺功能减低30例),甲亢211例(未治疗40例,抗甲状腺药物治疗中130例,^(131)I 治疗后41例)。结果:330例甲状腺疾病患者 Tg 基因位点脆性表达频率皆有不同程度的改变,无着丝粒断片和微核率明显增高。经^(131)I 治疗的21例甲状腺癌和41例甲亢病人,Fra8q22明显高于未经^(131)I 治疗的甲状腺癌和甲亢病人(t=7.349,P<0.01)。结论:^(131)I 辐射导致基因结构的损伤,8q22是受损伤的敏感位点。PURPOSE To study the value of thyroglobulin (Tg) gene activity changes in thyroid disease.METHODS Tg con- centration and gene activity was studied in 330 thyroid patients;including thyroid carcinoma 30 (^(131)I therapy 21 and operation 9), Hoshimoto's thyroditis 89 (thyroid function normal 59 and hypo 30) and hyperthyroidism 211 (untreated 40,antithyroid drug therapy 130,^(131)I therapy 41).RESULTS There were changes with various degree about fragile sites express frequence and signifi- cant elevation in acentric chromosome fragment,and micronucleus in 330 thyroid disease.In 21 thyroid carcinoma and 41 hyper- thyroidism treated by ^(131)I,Fra 8q22 markly increased than that of untreated groups (t=7.349,P<0.01).CONCLUSIONS ^(131)I irradiation leads to destruction of Tg gene structure and the 8q22 was the most sensitive one.

关 键 词：甲状腺疾病 甲状腺球蛋白 基因 

分 类 号：R581.02[医药卫生—内分泌]