276例药物性肝损伤的病因和临床表现分析  

An analysis of 276 cases of drug-induced liver damage

作　　者：陆玮婷[1] 李军[1] 欧宁[2] 陈念[1] 刘源[1] 郭雪江 王瑞云[1] 鲁翔[1] 黄峻[1] 

机构地区：[1]南京医科大学第一附属医院感染病科,210029 [2]南京医科大学第一附属医院药剂科,210029 [3]南京医科大学第一附属医院重点实验室,210029

出　　处：《中华肝脏病杂志》2006年第11期832-834,共3页Chinese Journal of Hepatology

摘　　要：目的探讨药物性肝损伤的病因及临床特点,以提高临床医师对该病的认识。方法对2000-2005年本院的药物性肝损伤病例276例进行回顾性研究,分析其所用药物、临床表现和转归等特点。结果引起肝损伤的药物种类繁多,中药占首位(26．1%),其次为抗肿瘤药物(17%)；引起的肝损伤以轻、中度为主,临床表现主要为乏力、纳差、尿黄、恶心和右上腹不适等；治疗后,88%治愈好转,而病死率为5．1%。结论致肝损伤的药物种类繁多,临床表现无特异性,但病死率较高,临床医师用药时应注意监测肝功能。Objective Drug-induced liver damage is a potential complication from using many drugs. The aim of our study was to analyze the etiology and clinical features of drug-induced liver damage, in order to draw more attention to this problem. Methods Two hundred and seventy-six cases over a 5-year period in Jiangsu Province Hospital were retrospectively analyzed. Results A variety of drugs, including traditional Chinese medicines （26.1% of our total cases） and anticancer drugs （1 7%） caused liver damage. The main clinical manifestations of it were fatigue, nausea, vomiting and jaundice. In 88% of our cases the symptoms were relieved or completely disappeared, but there was still a 5.1% mortality rate. Conclusions The clinical features of drug-induced liver damage are of no specificity, and the mortality of it is not low. Liver function should be monitored when suspected drugs are prescribed.

关 键 词：药用制剂 肝疾病 临床特点 

分 类 号：R595.3[医药卫生—内科学]