ACEI联合激素和低分子肝素治疗难治性肾病综合征30例  

Refractory nephrotic syndrome treated with ACEI combined with glucocorticoid and low molecular weight heparins:30 cases report

作　　者：钟建庭[1] 刘丽[1] 王璇[1] 席春生[1] 刘冬梅[1] 许瑞元[1] 陆伟[1] 

机构地区：[1]兰州军区兰州总医院普内科,甘肃兰州730050

出　　处：《第四军医大学学报》2006年第21期1988-1989,共2页Journal of the Fourth Military Medical University

摘　　要：目的:观察肾素-血管紧张素转换酶抑制剂(ACEI)联合激素和低分子肝素治疗难治性肾病综合征的近期疗效.方法:难治性肾病综合征患者30例接受苯那普利或卡托普利,泼尼松,低分子肝素钙治疗,全疗程60d.治疗结束后评定疗效,并观察24h尿蛋白定量,血浆蛋白,浮肿情况,肾功能及治疗中的不良反应等.结果:30例患者中临床完全缓解12例(40%),基本缓解12例(40%),部分缓解4例(13%),总有效率93%,部分相关生化指标有明显改善(P<0.01),未见明显副作用.结论:ACEI联合激素和低分子肝素治疗难治性肾病综合征具有良好的近期疗效,且副作用小,可在临床应用.AIM： To investigate the short-term curative effect of angiotensin-converting enzyme inhibitor （ACEI） combined with glucocorticoid and low molecular weight heparin （LMWH） on refractory nephrotic syndrome （RNS）. METHODS： Patients with RNS （n = 30） were administrated with benazepill or captopill, prednisone and LMWH for 60 d. Twenty-four-hour urine protein excretion, serum albumin, edema, renal function and side effects were observed after treatment. RESULTS： The clinical complete remission rate was 40% （n = 12） ; the basic remission rate was 40% （n = 12） ; the partial remission was 13% （n =4）. The overall effective rate was 93%. Most of biochemical index were improved （ P 〈 0.01 ） , and no obvious side effects were observed. CONCLUSION： ACEI combined with glucocorticoid and LMWH has a favorable short-term effect with fewer side effects, so it is a promising therapy for RNS.

关 键 词：肾素-血管紧张素转换酶抑制剂 激素 低分子量肝素 肾病综合征 

分 类 号：R692[医药卫生—泌尿科学]