2,6-二氯醌氯亚胺荷移分光光度法测定左旋多巴片的含量  

Spectrophotometry determination of levodopa in tablets based on charge transfer complex of levodopa with 2,6-dichloroquinone-4-chioroimide

作　　者：李省云[1] 杨毅萍[1] 陈艳芳[1] 

机构地区：[1]太原师范学院化学系,太原030001

出　　处：《药物分析杂志》2006年第10期1506-1507,共2页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的:研究分光光度法测定左旋多巴片的含量。方法:在硼砂溶液中,左旋多巴和2,6-二氯醌氯亚胺发生反应,生成荷移络合物。结果:络合物的λ_(max)=496nm,组成比为1:1,表观摩尔吸光系数ε=1.1×10~4 L·mol^(-1)·cm^(-1),线性范围为2.5～23.8μg·mL^(-1),回收率为96.81%～97.59%,RSD 为0.55%～0.60%。结论:应用本方法测定左旋多巴片的含量,得到满意的结果。Objective：To determination the content of levodopa in tablets by spectrophotometry. Method：It was based on charge transfer reaction of levodopa with 2,6 - dichloroquinone -4 - chloroimide in borax buffer solution. Resets：The apparent molar absorptivity of the complex was 1.1 10^4 L ·mol^-1 cm^-1 at 496 nm. The calibration curves was found to be linear in the range of 2.5 - 23.8 μg · mL^-1. The composition of the complex of levodopa with 2,6 -dichloroquinone -4 -chloroimide was 1： 1. Conclusion ：This method has been applied to the determination of levodop in tablets with satisfactory results.

关 键 词：荷移反应 分光光度法 左旋多巴 2 6-二氯醌氯亚胺 

分 类 号：R917[医药卫生—药物分析学]