^(99)Tc^m—TRODAT-1 SPECT脑显像在评价苍白球腹后部毁损术治疗帕金森病长期疗效中的价值  

^(99)Tc^m-TRODAT-1 SPECT Imaging for Monitoring The Long - term Effect of Posteroventral Pallidotomy in Parkinson's Disease

作　　者：段虎斌[1] 刘跃亭[1] 郝春艳[1] 陈来照[1] 蒯东[1] 范益民[1] 朱永梅[1] 

机构地区：[1]山西医科大学第一医院

出　　处：《中西医结合心脑血管病杂志》2006年第11期970-971,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：山西省卫生厅科技攻关计划基金项目(No.200502);山西医科大学第一医院基金项目(No.Y0517)

摘　　要：目的探讨99Tcm-TRODAT-1SPECT脑显像在评价苍白球腹后部毁损术(PVP)治疗帕金森病(PD)疗效中的应用价值。方法对13例单侧PVP手术治疗病人、31例内科治疗PD病人和10名健康人(健康对照组),行脑99Tcm-TRODAT-1SPECT断层显像,利用感兴趣区技术测定纹状体与小脑部位DAT比值。结果健康对照组双侧纹状体摄取差异无统计学意义,内科治疗组PD病人及单侧PVP手术治疗PD病人双侧纹状体与小脑部位DAT比值(ST/CB)分别较健康对照组明显降低(P<0.05),症状对侧较症状同侧ST/CBDAT比值明显降低(P<0.05),内科治疗组PD病人同PVP手术治疗PD病人双侧ST/CB差异无统计学意义(P>0.05),但UPDRS评分前者高于后者(P<0.05)。结论99Tcm-TRODAT-1SPECT脑显像结合UPDRS评分,有助于客观评价PVP手术治疗PD的疗效,加深对PVP手术原理的理解和认识,同时为评价其他PD术式的疗效,提供新的思路和方法。Objective To discuss ^99 Tc^m - TRODAT - 1 SPECT imaging for monitoring the long - term effect of posteroventral pallidotomy in Parkinson＇s Disease （PD）. Methods The PVP group （31 pts with PD）, non-PVP group （31 pts with PD） and a control group （10 healthy subjects） were chosen to conduct dopamine transporter （DAT） imaging by SPECT with ^99 Tc^m - TRODAT - 1. The radioactive ratio between bilateral striatum and cerebellum （ST/CB） were computed by the region of interest （ROI） technology. Meanwhile, the PD pts were evaluated by Unified Parkinson＇ s Disease Rating Scale （UPDRS）. Results The UPDRS score of PVP group were lower than that of non - PVP group（ P 〈 0.05）. The bilateral ST/CB mean of the PVP group and that of non - PVP group had no significant difference（P 〉0.05 ）. But the bilateral ST/CB mean of two groups were lower than that of healthy subjects. （ P 〈 0.05） Conclusion The dopamine transporter imaging by SPECT with ^99Tc^m - TRO- DAT- 1 could monitor the long - term effect of PVP.

关 键 词：^99TC^M-TRODAT-1 多巴胺转运蛋白 单光子发射型计算机断层显像 帕金森病 苍白球腹后部毁损术 

分 类 号：R651.1[医药卫生—外科学]