非天然有机分子折叠体的组装及其对有机分子和离子的识别研究(英文)  

The Self-assembly of Folding Architectures and Their Applications in Molecular Recognition

作　　者：侯军利[1] 蒋锡夔[1] 黎占亭[1] 

机构地区：[1]中国科学院上海有机化学研究所生命有机化学国家重点实验室,上海200032

出　　处：《中国科学院研究生院学报》2006年第6期842-847,共6页Journal of the Graduate School of the Chinese Academy of Sciences

基　　金：the Ministry of Science and Technology(200007801),the National Natural Science Foundation of China(20321202,90206005,20372080,20332040,20425208),and the Chinese Academy of Sciences.

摘　　要：分子折叠体是一类由非共价键稳定的、采用有序构象的寡聚物或聚合物.我们设计并合成了三类非天然的折叠体,包括:(1)由疏溶剂作用驱动的并入萘环板块的寡聚乙二醇折叠体,(2)由分子内氢键驱动的寡聚酰肼折叠体,(3)由分子内氢键驱动的并入锌卟啉板块的寡聚苯酰胺折叠体.定性和定量的研究揭示,在有机溶剂中这些折叠体可以作为非天然受体分子高效络合或识别结构匹配的有机分子和离子,并且氢键驱动的折叠体可以通过络合作用实现超分子体系的手性诱导或手性放大.Foldamers are linear molecules that are driven by collective noncovalent forces to fold into a conformationally ordered state in a solution or solid state. Three kinds of foldamers have been designed, synthesized and characterized, which include： （1） solvophobically-driven oligo（ethylene glycol） helical foldamers, （2） hydrogen bonded oligohydrazide foldamers and （3） hydrogen-bonded porphyrin-appended foldamers. The qualitative and quantitative investigations by NMR, UV-vis, fluorescent, and circular dichroism spectroscopy revealed that these foldamers can act as efficient receptors for discrete kinds of organic molecules and ions in different organic solvents. The supramolecular chiral induction or amplification has also been investigated for the hydrogen bonded folding systems .

关 键 词：非天然折叠体 组装 疏溶剂作用 氢键制备 手性诱导 分子识别 

分 类 号：O621[理学—有机化学]