P物质和P物质受体在小鼠胚胎发育期脑内的表达  

THE EXPRESSION OF SUBSTANCE P AND SUBSTANCE P RECEPTOR IN THE DEVELOPMENT OF MOUSE BRAIN

作　　者：季华[1] 韩曙[1] 郑轶[1] 孙建刚[1] 凌树才[1] 

机构地区：[1]浙江大学医学院人体解剖学教研室,杭州310031

出　　处：《解剖学报》2006年第5期578-583,共6页Acta Anatomica Sinica

基　　金：国家自然科学基金资助项目(30570586)

摘　　要：目的研究小鼠胚脑发育期间P物质(SP)和P物质受体(SPR)的表达。方法分别取孕11、13、15、17和19d的小鼠胚脑和新生鼠脑,采用SP和SPR酶标免疫组织化学染色观察SP和SPR表达的变化。结果SP自小鼠胚胎11d开始出现少量表达,并一直持续到出生后,主要出现在发育过程中的新纹状体等部位;SPR与SP同时出现并持续到出生后,主要出现在发育过程中的延髓中缝等部位。结论SP和SPR在小鼠发育期间的表达提示SP可能参与中枢神经系统神经元形成和成熟调控。Objective To study the expression of substance P （SP） and substance P receptor （SPR） during the development of mice brains. Methods The expression of SP and SPR during the development of mice brains from embryonic day （E） 11 to postnatal day（P） 0 days was analyzed by immunohistocbemical method. Results The expression of SP began at Ell and gradually increased until birth. The expression of SPR began at Ell and maintained stable expression until birth. SP mostly expressed at striatum and SPR mostly expressed at medullary raphe. Conclusion The expression of SP and SPR during the embryo brain stage may indicate that SP could be an important factor involved in the early organization and maturation of neuron.

关 键 词：P物质 P物质受体 神经发育 免疫组织化学 小鼠 

分 类 号：R322.8[医药卫生—人体解剖和组织胚胎学]