高强度聚焦超声抗大鼠早孕的蜕膜细胞凋亡机制  

Anti-gestation Mechanism of High Intensity Focused Ultrasound in Rats:Decidua Cell Apoptosis

作　　者：郑蓉[1] 李晓艳[1] 吴大琼[1] 王瑞玲[1] 李洪发[1] 王泽华[1] 

机构地区：[1]华中科技大学同济医学院协和医院妇产科,武汉市430022

出　　处：《中国超声医学杂志》2006年第11期810-812,共3页Chinese Journal of Ultrasound in Medicine

基　　金：湖北省计生委科研基金资助项目(No.GS2003-05)

摘　　要：目的探讨HIFU抗早孕蜕膜细胞凋亡的机制。方法HIFU以10W/cm2辐照孕8d大鼠子宫90s。TUNEL法与免疫组织化学法检测蜕膜细胞凋亡及bcl-2和bax蛋白表达。结果辐照后蜕膜细胞凋亡率及bax/bcl-2比值均高于对照组(P<0.05)。结论HIFU诱导蜕膜细胞凋亡是其抗早孕机理之一,bax/bcl-2比值增高参与了蜕膜细胞凋亡调控。Objective To study the probable mechanism of rat abortion induced by high intensity focused ultrasound （HIFU） .Methods Rats with 8-day gestation were radiated with HIFU. The controlled group was established without radiation. Decidua cell apoptosis and the expressions of bcl-2 and bax were examined via TUNEL and immunohistochemical method. Results Decidua apoptosis rate of the experimental group was higher than that of the control group （P 〈 0.05） .The bax /bcl-2 was higher than that of the control group （P〈 0.05） . Conclusions The decidua cell apoptosis induced by HIFU in rats might be associated with the bax and bcl-2,and may be one of the mechanisms of early anti-gestation.

关 键 词：高强度聚焦超声 蜕膜细胞 凋亡 抗早孕 

分 类 号：R454[医药卫生—治疗学] R169.42[医药卫生—临床医学]