蛋白酪氨酸磷酸酶-1B与2型糖尿病  

Protein tyrosine phosphatase 1B and type 2 diabetes

作　　者：王淼[1] 邹大进[1] 

机构地区：[1]第二军医大学长海医院内分泌科,上海200433

出　　处：《国际内分泌代谢杂志》2006年第6期388-390,共3页International Journal of Endocrinology and Metabolism

摘　　要：研究证实,蛋白酪氨酸磷酸酶-1B(PTP-1B)主要通过以下几方面参与2型糖尿病的发病(1)可与胰岛素受体及其底物相作用,减弱胰岛素信号转导,引起胰岛素抵抗。(2)参与对胰岛β细胞数量的调节。(3)与瘦素抵抗及脂代谢异常关系密切,由此引发并加重2型糖尿病。目前已合成各种类型的PTP-1B抑制剂,有良好的降糖等疗效,临床应用前景广阔。Protein tyrosine phosphatase 1B（PIP-1B） is proved to contribute to the pathogenesis of type 2 diabetes through the following ways： （1） PIP- 1B is associated with insulin receptor and down regulates insulin signaling which causes insulin resistance. （2） PIP-1B participates in the regulation of pancreas beta ceils mass. （3） PIP-1B may play a role in leptin resistance and lipid metabolism disorder. All of this promote the pathogenesis and development of type 2 diabetes. Several kinds of PIP-1B inhibitors have been synthetized which can normalize hyperglycaemia, and have spacious prospect of clinical application.

关 键 词：蛋白酪氨酸磷酸酶-1B 2型糖尿病 胰岛素抵抗 蛋白酪氨酸磷酸酶-1B抑制剂 

分 类 号：R587.1[医药卫生—内分泌]