肿瘤坏死因子-α与糖尿病视网膜病变关系的研究进展  

Tumor necrosis factor-α and diabetic retinopathy

作　　者：张运利[1] 孙照霞[1] 翟慎华[1] 

机构地区：[1]济南市第二人民医院内科,250001

出　　处：《国际内分泌代谢杂志》2006年第6期403-404,411,共3页International Journal of Endocrinology and Metabolism

摘　　要：肿瘤坏死因子(TNF)-α通过其细胞膜上的受体在免疫和非免疫系统中发挥着许多不同作用。研究表明,糖尿病视网膜病变患者血清及玻璃体视网膜局部均可检测到TNF-α,且随病变进展血清中TNF-α水平升高。推测TNF-α可能通过直接损伤血—视网膜屏障,提高视网膜血管通透性,诱导其他细胞因子释放,提高靶细胞的反应性,以及诱导、加重胰岛素抵抗的产生,在糖尿病视网膜病变的发生、发展中起非常重要的作用。Tumor necrosis factor（TNF）-α exerts numerous functions in the immune and non-immune system through its receptors located on the cellular membrane. Some evidences show that TNF-α is detected in the serum, vitreous body and retina of diabetic patients. Moreover, the levels of TNF-α in the serum step up following the development of diabetic retinopathy（DR）. TNF-α might be associated with DR by directly impairing the bloodretinal barriers, promoting retinal vessels＇ penneabilities, increasing the secretion of other cytokines and their reactivities towards the target cells, inducing and aggravating the insulin resistance, etc.

关 键 词：肿瘤坏死因子-Α 糖尿病视网膜病变 血-视网膜屏障 细胞因子 

分 类 号：R587.2[医药卫生—内分泌]