头孢唑林钠结晶热力学  

Crystallization thermodynamics of cefazolin sodium pentahydrate

作　　者：武洁花[1] 王静康[1] 尹秋响[1] 张美景[1] 

机构地区：[1]天津大学化工学院国家工业结晶技术研究推广中心,天津300072

出　　处：《中国抗生素杂志》2006年第11期665-668,共4页Chinese Journal of Antibiotics

摘　　要：采用差热分析法测定头孢唑林钠的分解温度和分解热;采用激光法测定头孢唑林钠在不同配比的水-乙醇、水-丙酮、水-异丙醇混合溶剂中的溶解度数据,采用指数模型对溶解度数据进行关联;最后测定头孢唑林钠在水及水与异丙醇混合溶剂中的冷却结晶介稳区数据,为头孢唑林钠的工业生产提供热力学依据。The decomposition temperature and heat of cefazolin sodium pentahydrate were measured by the differential scanning calorimetry technique. Its solubility data in various mixed solvents of water-ethanol, water-acetone, and water-2-propanol were obtained by the laser method and fitted by the exponential model. Finally, the crystallization metastable zone of cefazolin sodium pentahydrate in water and the mixture of water and 2-propanol at different temperatures was determined by the laser method. Valuable thermodynamics data for the industrial manufacture of cefazolin sodium pentahydrate were obtained.

关 键 词：头孢唑林钠 结晶 热力学 介稳区 

分 类 号：R378.11[医药卫生—病原生物学]