妊娠引起的药动学变化  

Changes of pharmacokinetics during pregancy

作　　者：道毅俊[1] 焦正[1] 李中东[1] 施孝金[1] 钟明康[1] 

机构地区：[1]复旦大学附属华山医院临床药学研究室,上海200052

出　　处：《中国新药与临床杂志》2006年第11期861-864,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：妊娠使人体的生理发生变化,从而影响代谢酶活性和肾排泄能力,使药物的血浆浓度发生改变,因此需要调整药物剂量。本文从药物的吸收、分布、代谢和排泄4个方面概述了因妊娠而引起的药动学改变。Pregnancy can induce changes in physiology, metabolic isoenzymes activity, renal excretion, and plasma concentrations of drugs. So it is needed to adjust drug dosage during pregnancy. This review evaluates pregnancy-induced pharmacokinetics changes from aspects of absorption, distribution, metabolism and excretion.

关 键 词：妊娠 药动学 细胞色素P450 葡糖醛酸基转移酶 

分 类 号：R969.1[医药卫生—药理学] R714.3[医药卫生—药学]