挤出滚圆法制备当归补血微丸的处方及工艺优化  

Formula and process optimization of Danggui Buxue Pellets prepared by extrusion-spheronization

作　　者：陈红霞[1] 贾晓斌[2] 陈彦[2] 施亚芳[2] 孙晶[3] 

机构地区：[1]江苏大学药学院,江苏镇江212001 [2]江苏省中医药研究院,江苏南京210028 [3]江苏大学生物与环境工程学院,江苏镇江212013

出　　处：《中成药》2006年第11期1565-1568,共4页Chinese Traditional Patent Medicine

基　　金：江苏省135工程重点人才资助项目(课题编号:65RC2002065)

摘　　要：目的:应用挤出滚圆法制备复方当归补血微丸,研究微丸制备的最佳工艺和处方。方法:用新型的挤出滚圆造粒机制备当归补血微丸;采用单因素考察和正交设计筛选最优处方和工艺条件;考察了微丸的粉体学性质和收率。结果:用挤出滚圆技术制备的当归补血微丸圆整度好,大小均匀,收率在85%以上。结论:挤出滚圆法可以制备中药微丸。该工艺简便易行,制得的微丸质量好,收率高。AIM： To prepare traditional Chinese medicine formula Danggui Buxue Pellets by extrusion-spheronization and to study the optimal process and formulation. METHODS： Danggui Buxue Pellets were prepared by a new style extrusion- spheronization equipment; The optimal process and formulation were obtained on the studies of influenitial factors and L9 （34 ） orthogonal design, The mieromeritic properties and reception percentage of pellets were determined. RESULTS： The prepared Danggui Buxue Pellets by extrusion-spheronization were all spheral with smooth surface ; The percent of reception was not less than 85%. CONCLUSIONS ： Extrusion-spheronization is suitable to produce herbal medicine pellets. The preparation process is simple and feasible; The quality of the prepared pellets is excellent and the percent of reception is high.

关 键 词：当归补血复方 挤出滚圆法 微丸 粉体学性质 

分 类 号：R944.22[医药卫生—药剂学]