心力衰竭时肺静脉形态与组织结构和心房颤动关系研究  

A relationship study on pulmonary vein morphology and histology and atrial fibrillation in heart failure

作　　者：高磊[1] 王士雯[1] 

机构地区：[1]解放军总医院老年心血管病研究所,100853

出　　处：《世界急危重病医学杂志》2006年第6期1561-1562,共2页internationl journal of emergency and critical care medicine

摘　　要：本研究拟从HF时PV形态、组织结构特征入手，初步揭示HF时PV异常电活动的产生和维持机制。为下一步以PV作为治疗靶点，进行相应的药物和非药物治疗，从而打破HF与AF之间的恶性循环提供理论依据。PART I A relationship study on ostia PVs morphology and AF in patients with HF Objective The purpose of this study was to investigate the relationship between ostia PVs morphology and AF in patients with HF by MDCT angiography using a new 64-slice scanner. Methods The study included 75 patients. Group I included 35 patients with HF, group Ⅱ included 19 patients with HF and chronic AF, group Ⅲ included 21 patients without the history of documented HF and AF. Age and concomitant heart diseases were similar among the three groups. By 64-slices MDCT with three-dimensional reconstruction, we measured the diameter of each PV ostium at its junction with the LA in two directions （AP and SI） in addition to LA maximal transverse, maximal AP, and SI dimensions on coronal and transverse sections. Results HF with or witout AF patients had significant dilation of all the four PVs and LA compared wth patients without HF. In group Ⅱ, the diameters of ostia PVs and LA were significantly enlarged than those in group Ⅰ. The diameters of all the four PVs and LA were found to be significantly increased from NYHA Ⅱ to NYHA Ⅳin group Ⅰ. Conclusions Significant dilation of the four PVs ostia with simultaneous LA enlargement was demonstrated in HF patients. The anatomic and geometric changes in PVs and LA may participate in initiation and perpetuation of AF in patients with HF.

关 键 词：组织结构特征 心房颤动 心力衰竭 形态 肺静脉 非药物治疗 异常电活动 维持机制 

分 类 号：R641[医药卫生—外科学]